Drug Information

Drug General Information

Drug ID

DMD26W

Drug Name

CRV431

Synonyms

UNII-M3H4D91AY5; M3H4D91AY5; CRV-431; CHEMBL4297487; CPI-431; CPI-431-32; N-((7R,8R)-8-((2S,5S,8R,11S,14S,17S,20S,23R,26S,29S,32S)-5-Ethyl-11,17,26,29-tetraisobutyl-14,32-diisopropyl-1,7,8,10,16,20,23,25,28,31-decamethyl-3,6,9,12,15,18,21,24,27,30,33-undecaoxo-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2-yl)-8-H

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Drug Type

Small molecular drug

Indication

Non-alcoholic steatohepatitis [ICD-11: DB92.1; ICD-10: K75.8; ICD-9: 571.8]

Phase 2

[1]

Company

Hepion Pharmaceuticals

Structure

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2D MOL

Formula

C67H122N12O13

Canonical SMILES

CCC1C(=O)N(C(C(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N1)C(C(C)CCCCCCNC(=O)C)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C)C

InChI

1S/C67H122N12O13/c1-26-48-63(88)73(19)46(17)62(87)74(20)50(34-38(4)5)59(84)72-53(41(10)11)66(91)75(21)49(33-37(2)3)58(83)69-44(15)57(82)70-45(16)61(86)76(22)51(35-39(6)7)64(89)77(23)52(36-40(8)9)65(90)78(24)54(42(12)13)67(92)79(25)55(60(85)71-48)56(81)43(14)31-29-27-28-30-32-68-47(18)80/h37-46,48-56,81H,26-36H2,1-25H3,(H,68,80)(H,69,83)(H,70,82)(H,71,85)(H,72,84)/t43-,44+,45-,46-,48+,49+,50+,51+,52+,53+,54+,55+,56-/m1/s1

InChIKey

KBARHGHBFILILC-NGIJKBHDSA-N

CAS Number

CAS 1383420-08-3

PubChem Compound ID

134812041

References

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REF 1

ClinicalTrials.gov (NCT04480710) A Study of CRV431 Dosed Once Daily in NASH Induced F2 and F3 Subjects (AMBITION). U.S. National Institutes of Health.

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