Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
DM16HS
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| Drug Name |
JAB-3068
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| Synonyms |
SHP2-IN-6; SCHEMBL19704279; JAB3068; NSC827676; NSC-827676; HY-131132; CS-0129188; 2169223-48-5
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| Drug Type |
Small molecular drug
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| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C00-D48; ICD-9: 140-199] | Phase 1 | [1] | |
| Company |
AbbVie; Jacobio Pharmaceuticals
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| Structure |
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Download2D MOL |
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| Formula |
C22H26F2N6O2S
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| Canonical SMILES |
CC(=O)N1CC(C2=C1C=CC=C2SC3=NC=C(N=C3N)N4CCC5(CC4)COCC5N)(F)F
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| InChI |
1S/C22H26F2N6O2S/c1-13(31)30-11-22(23,24)18-14(30)3-2-4-15(18)33-20-19(26)28-17(9-27-20)29-7-5-21(6-8-29)12-32-10-16(21)25/h2-4,9,16H,5-8,10-12,25H2,1H3,(H2,26,28)/t16-/m1/s1
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| InChIKey |
HGYTYZKWKUXRKA-MRXNPFEDSA-N
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| PubChem Compound ID | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT03518554) A First in Human, Dose Escalation Study of JAB-3068 (SHP2 Inhibitor) in Adult Patients With Advanced Solid Tumors. U.S. National Institutes of Health. | |||
| REF 2 | Clinical pipeline report, company report or official report of AbbVie. | |||
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