Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
DLQS16
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| Drug Name |
ION904
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| Synonyms |
tonlamarsen
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|
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| Drug Type |
RNA interference
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| Indication | Hypertension [ICD-11: BA00-BA04; ICD-9: 401] | Phase 2 | [1] | |
| Company |
Ionis Pharmaceuticals
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Angiotensinogen messenger RNA (AGT mRNA) | Target Info | . | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT05314439) A Double-Blind, Placebo-Controlled, Phase 2 Study to Assess the Safety, Tolerability and Efficacy of Monthly Subcutaneous Administration of ION904 in Patients With Uncontrolled Hypertension. U.S.National Institutes of Health. | |||
| REF 2 | Antisense oligonucleotides targeting hepatic angiotensinogen reduce atherosclerosis and liver steatosis in hypercholesterolemic mice. Glob Transl Med. 2023;2(1):288. | |||
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