Drug Information
| Drug General Information | Top | |||
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| Drug ID |
DJ74CB
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| Drug Name |
VK-0214
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| Synonyms |
6FGG71NJ3Y; VK0214; VK-0214; UNII-6FGG71NJ3Y; (((4-(3-Benzyl-4-hydroxybenzyl)-3,5-dimethylphenyl)oxy)methyl)phosphonic acid; ((4-(3-Benzyl-4-hydroxybenzyl)-3,5-dimethylphenoxy)methyl)phosphonic acid; Phosphonic acid, P-((4-((4-hydroxy-3-(phenylmethyl)phenyl)methyl)-3,5-dimethylphenoxy)methyl)-; 852949-30-5; SCHEMBL283442; CHEMBL4802139
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| Drug Type |
Small molecule
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| Indication | X-linked Adrenoleukodystrophy [ICD-11: 5C57] | Phase 1 | [1] | |
| Company |
Viking Therapeutics San Diego, CA
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| Structure |
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Download2D MOL |
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| Formula |
C23H25O5P
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| Canonical SMILES |
CC1=CC(=CC(=C1CC2=CC(=C(C=C2)O)CC3=CC=CC=C3)C)OCP(=O)(O)O
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| InChI |
InChI=1S/C23H25O5P/c1-16-10-21(28-15-29(25,26)27)11-17(2)22(16)14-19-8-9-23(24)20(13-19)12-18-6-4-3-5-7-18/h3-11,13,24H,12,14-15H2,1-2H3,(H2,25,26,27)
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| InChIKey |
GFJCILQBXUTOGN-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Thyroid hormone receptor beta (THRB) | Target Info | Agonist | [2] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Thyroid hormone signaling pathway | ||||
| Pathway Interaction Database | RXR and RAR heterodimerization with other nuclear receptor | |||
| Reactome | Nuclear Receptor transcription pathway | |||
| WikiPathways | SIDS Susceptibility Pathways | |||
| Hematopoietic Stem Cell Differentiation | ||||
| Nuclear Receptors | ||||
| References | Top | |||
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| REF 1 | ClinicalTrials.gov (NCT04973657) Phase 1b, Multi-center, Randomized, Double-Blind, Placebo-Controlled, Study to Evaluate the Safety, Tolerability, PD and PK of VK0214, in Subjects With the Adrenomyeloneuropathy Form (AMN) of X-linked Adrenoleukodystrophy (X-ALD). U.S.National Institutes of Health. | |||
| REF 2 | Clinical pipeline report, company report or official report of Viking Therapeutics | |||
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