Drug Information
Drug General Information | Top | |||
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Drug ID |
DHY6S0
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Drug Name |
Arfolitixorin
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Synonyms |
(6R)-5,10-Methylenetetrahydrofolate; Modufolin; UNII-Z8R4A37V9Q; 31690-11-6; Methylenetetrahydrofolic acid, L-(+)-; (6R)-5,10-methylenetetrahydrofolic acid; CHEBI:1989; Z8R4A37V9Q; L-(+)-methylenetetrahydrofolic acid; 31690-11-6 (free); 5,10-methylene-THF; 5,10-methylenetetrahydrofolate; 3432-99-3; (4-((R)-3-amino-1-oxo-1,2,5,6,6a,7-hexahydroimidazo[1,5-f]pteridin-8(9H)-yl)benzoyl)-L-glutamic acid; N-({4-[(6ar)-3-Amino-1-Oxo-1,2,5,6,6a,7-Hexahydroimidazo[1,5-F]pteridin-8(9h)-Yl]phenyl}carbonyl)-L-Glutamic Acid; N-{4-[(6aR)-3-amino-1-oxo-1,2,5,6,6a,7-hexahydroimidazo[1,5-f]pteridin-8(9H)-yl]benzoyl}-L-glutamic acid; Arfolitixorin [USAN]; 6R-MTHF; Arfolitixorin (USAN/INN); SCHEMBL186747; CHEMBL1234270; DTXSID60185584; ISO-901; BCP09003; ZINC4228243; (6R)-5,10-MTHF; WHO 10689; DB12676; 5,10-methylene-(6r)-tetrahydrofolic acid; 5,10-methylene,5,6,7,8-tetrahydrofolate; D11447; Q26995704; (6r,s)-5,10-methylene-5,6,7,8-tetrahydrofolic acid; [6R]-5,10-methylenetetrahydrofolate ([6R]-5,10- MTHF); UNII-0SXY5ET48B component QYNUQALWYRSVHF-OLZOCXBDSA-N; (S)-2-(4-((R)-3-Amino-1-oxo-5,6,6a,7-tetrahydroimidazo[1,5-f]pteridin-8(1H,4H,9H)-yl)benzamido)pentanedioic acid; N-({4-[(6aR)-3-amino-1-oxo-1,4,5,6,6a,7-hexahydroimidazo[1,5-f]pteridin-8(9H)-yl]phenyl}carbonyl)-L-glutamic acid
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Drug Type |
Small molecular drug
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Indication | Colorectal cancer [ICD-11: 2B91.Z] | Phase 3 | [1] | |
Company |
Isofol Medical
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Structure |
Download2D MOL |
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Formula |
C20H23N7O6
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Canonical SMILES |
C1C2CN(CN2C3=C(N1)N=C(NC3=O)N)C4=CC=C(C=C4)C(=O)NC(CCC(=O)O)C(=O)O
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InChI |
1S/C20H23N7O6/c21-20-24-16-15(18(31)25-20)27-9-26(8-12(27)7-22-16)11-3-1-10(2-4-11)17(30)23-13(19(32)33)5-6-14(28)29/h1-4,12-13H,5-9H2,(H,23,30)(H,28,29)(H,32,33)(H4,21,22,24,25,31)/t12-,13+/m1/s1
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InChIKey |
QYNUQALWYRSVHF-OLZOCXBDSA-N
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CAS Number |
CAS 31690-11-6
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PubChem Compound ID | ||||
ChEBI ID |
CHEBI:1989
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References | Top | |||
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REF 1 | ClinicalTrials.gov (NCT03750786) A Study to Compare the Efficacy of Arfolitixorin Versus Leucovorin in Combination With 5 Fluorouracil, Oxaliplatin, and Bevacizumab in Patients With Advanced Colorectal Cancer (AGENT). U.S. National Institutes of Health. |
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