Drug Information
| Drug General Information | Top | |||
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| Drug ID |
DHG36S
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| Drug Name |
ETP-45658
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| Synonyms |
1198357-79-7; ETP 45658; 3-(1-methyl-4-morpholin-4-ylpyrazolo[3,4-d]pyrimidin-6-yl)phenol; 3-(4-Morpholino-1-methyl-1H-pyrazolo[3,4-d]pyrimidine-6-yl)phenol; 3-[1-Methyl-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenol; CHEMBL4303351; SCHEMBL12684765; BDBM92585; ETP45658; ZINC59155589; AKOS025293482; ETP-45658, 13; 3-[1-Methyl-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-6-ylphenol
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| Drug Type |
Small molecular drug
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| Indication | Breast cancer [ICD-11: 2C60-2C65; ICD-10: C50, C79.51] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C16H17N5O2
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| Canonical SMILES |
CN1C2=C(C=N1)C(=NC(=N2)C3=CC(=CC=C3)O)N4CCOCC4
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| InChI |
1S/C16H17N5O2/c1-20-15-13(10-17-20)16(21-5-7-23-8-6-21)19-14(18-15)11-3-2-4-12(22)9-11/h2-4,9-10,22H,5-8H2,1H3
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| InChIKey |
BJVRNXSHJLDZJR-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | PI3-kinase (PIK3C) | Target Info | Inhibitor | [1] |
| References | Top | |||
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| REF 1 | A novel phosphatidylinositol 3-kinase (PI3K) inhibitor directs a potent FOXO-dependent, p53-independent cell cycle arrest phenotype characterized by the differential induction of a subset of FOXO-regulated genes. Breast Cancer Res. 2014 Dec 9;16(6):482. | |||
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