Drug Information
| Drug General Information | Top | |||
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| Drug ID |
DAT0U5
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| Drug Name |
NV-5138
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| Synonyms |
UNII-06CA9QMG6Z; 4-(difluoromethyl)-L-leucine; 2095886-80-7; SCHEMBL18762589; ZINC585143195; HY-114384; N[C@H](C(=O)O)CC(C(F)F)(C)C; CS-0084893; ((S)-2-Amino-5,5-difluoro-4,4-dimethylpentanoic acid; Pentanoic acid, 2-amino-5,5-difluoro-4,4-dimethyl-, (2S)-; K94
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| Drug Type |
Small molecular drug
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| Indication | Major depressive disorder [ICD-11: 6A70.3; ICD-10: F32.2; ICD-9: 296.2, 296.3] | Phase 1 | [1] | |
| Company |
Navitor Pharmaceuticals
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| Structure |
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Download2D MOL |
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| Formula |
C7H13F2NO2
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| Canonical SMILES |
CC(C)(CC(C(=O)O)N)C(F)F
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| InChI |
1S/C7H13F2NO2/c1-7(2,6(8)9)3-4(10)5(11)12/h4,6H,3,10H2,1-2H3,(H,11,12)/t4-/m0/s1
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| InChIKey |
HRFIMCJTDKEPPV-BYPYZUCNSA-N
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| CAS Number |
CAS 2095886-80-7
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Mammalian target of rapamycin complex 1 (mTORC1) | Target Info | Activator | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT03606395) Safety, Tolerability, PK and Efficacy of Single Doses of NV-5138 in Healthy Volunteers and Subjects With Treatment-Resistant Depression. U.S. National Institutes of Health. | |||
| REF 2 | Sestrin modulator NV-5138 produces rapid antidepressant effects via direct mTORC1 activation. J Clin Invest. 2019 Apr 16;129(6):2542-2554. | |||
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