Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D87TMY
|
|||
| Drug Name |
OT-58
|
|||
| Drug Type |
Recombinant protein
|
|||
| Indication | Homocystinuria [ICD-11: 5C50.B; ICD-10: E72.1] | Phase 1/2 | [1] | |
| Company |
Orphan Technologies
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Cystathionine beta-synthase (CBS) | Target Info | Replacement | [2] |
| BioCyc | Hydrogen sulfide biosynthesis (trans-sulfuration) | |||
| Cysteine biosynthesis/homocysteine degradation (trans-sulfuration) | ||||
| Superpathway of methionine degradation | ||||
| Cysteine biosynthesis | ||||
| KEGG Pathway | Glycine, serine and threonine metabolism | |||
| Cysteine and methionine metabolism | ||||
| Metabolic pathways | ||||
| Biosynthesis of antibiotics | ||||
| Biosynthesis of amino acids | ||||
| NetPath Pathway | TGF_beta_Receptor Signaling Pathway | |||
| Panther Pathway | Cysteine biosynthesis | |||
| Pathwhiz Pathway | Selenoamino Acid Metabolism | |||
| Homocysteine Degradation | ||||
| Methionine Metabolism | ||||
| Glycine and Serine Metabolism | ||||
| WikiPathways | Vitamin D Receptor Pathway | |||
| Metabolism of amino acids and derivatives | ||||
| Trans-sulfuration and one carbon metabolism | ||||
| Trans-sulfuration pathway | ||||
| Folate Metabolism | ||||
| Folate-Alcohol and Cancer Pathway | ||||
| Vitamin B12 Metabolism | ||||
| Selenium Micronutrient Network | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT03406611) OT-58 as an Enzyme Therapy for Patients With Homocystinuria Caused by Cystathionine Beta-Synthase Deficiency. U.S. National Institutes of Health. | |||
| REF 2 | Classical homocystinuria: From cystathionine beta-synthase deficiency to novel enzyme therapies. Biochimie. 2020 Jun;173:48-56. | |||
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