Drug Information
Drug General Information | Top | |||
---|---|---|---|---|
Drug ID |
D7FJX0
|
|||
Drug Name |
AST-004
|
|||
Indication | Stroke [ICD-11: 8B20; ICD-10: G45.9, I61-I63; ICD-9: 434.91, 435.9] | Phase 1 | [1] | |
Company |
Astrocyte Pharmaceuticals
|
Target and Pathway | Top | |||
---|---|---|---|---|
Target(s) | Adenosine A1 receptor (ADORA1) | Target Info | Agonist | [2] |
Adenosine A3 receptor (ADORA3) | Target Info | Agonist | [2] | |
KEGG Pathway | cGMP-PKG signaling pathway | |||
cAMP signaling pathway | ||||
Sphingolipid signaling pathway | ||||
Neuroactive ligand-receptor interaction | ||||
Morphine addiction | ||||
NetPath Pathway | TCR Signaling Pathway | |||
RANKL Signaling Pathway | ||||
Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | ||||
Reactome | Adenosine P1 receptors | |||
G alpha (i) signalling events | ||||
WikiPathways | Nucleotide GPCRs | |||
GPCRs, Class A Rhodopsin-like | ||||
GPCRs, Other | ||||
GPCR ligand binding | ||||
GPCR downstream signaling |
References | Top | |||
---|---|---|---|---|
REF 1 | Clinical pipeline report, company report or official report of Astrocyte Pharmaceuticals | |||
REF 2 | Adenosine A1R/A3R (Adenosine A1 and A3 Receptor) Agonist AST-004 Reduces Brain Infarction in a Nonhuman Primate Model of Stroke. Stroke. 2022 Jan;53(1):238-248. |
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