Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D6QA4N
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| Drug Name |
S-(2-Aminophenyl)-L-cysteine S,S-dioxide
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| Synonyms |
SCHEMBL9065263
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| Drug Type |
Small molecular drug
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| Indication | Bacterial infection [ICD-11: 1A00-1C4Z; ICD-10: A00-B99] | Preclinical | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C9H12N2O4S
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| Canonical SMILES |
C1=CC=C(C(=C1)N)S(=O)(=O)CC(C(=O)O)N
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| InChI |
1S/C9H12N2O4S/c10-6-3-1-2-4-8(6)16(14,15)5-7(11)9(12)13/h1-4,7H,5,10-11H2,(H,12,13)/t7-/m0/s1
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| InChIKey |
JJUXYMMPJKOKBD-ZETCQYMHSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Kynureninase (KYNU) | Target Info | Inhibitor | [2] |
| BioCyc | Superpathway of tryptophan utilization | |||
| Tryptophan degradation | ||||
| L-kynurenine degradation | ||||
| Tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde | ||||
| NAD de novo biosynthesis | ||||
| KEGG Pathway | Tryptophan metabolism | |||
| Metabolic pathways | ||||
| NetPath Pathway | TSLP Signaling Pathway | |||
| Pathwhiz Pathway | Tryptophan Metabolism | |||
| Reactome | Tryptophan catabolism | |||
| WikiPathways | Tryptophan metabolism | |||
| Metabolism of amino acids and derivatives | ||||
| NAD Biosynthesis II (from tryptophan) | ||||
| Selenium Micronutrient Network | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond. Nat Rev Drug Discov. 2019 May;18(5):379-401. | |||
| REF 2 | Structure, mechanism, and substrate specificity of kynureninase. Biochim Biophys Acta. 2011 Nov;1814(11):1481-8. | |||
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