Drug Information
Drug General Information | Top | |||
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Drug ID |
D5S7JL
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Drug Name |
ODN-1411
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Drug Type |
Oligonucleotide
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Indication | Rheumatoid arthritis [ICD-11: FA20; ICD-9: 729] | Investigative | [1] |
Target and Pathway | Top | |||
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Target(s) | Toll-like receptor 8 (TLR8) | Target Info | Inhibitor | [1] |
KEGG Pathway | Toll-like receptor signaling pathway | |||
NetPath Pathway | Leptin Signaling Pathway | |||
TCR Signaling Pathway | ||||
Panther Pathway | Toll receptor signaling pathway | |||
Reactome | Trafficking and processing of endosomal TLR | |||
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling | ||||
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | ||||
MyD88 dependent cascade initiated on endosome | ||||
WikiPathways | Toll-like receptor signaling pathway | |||
Toll-Like Receptors Cascades | ||||
MyD88 dependent cascade initiated on endosome | ||||
Trafficking and processing of endosomal TLR | ||||
Regulation of toll-like receptor signaling pathway |
References | Top | |||
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REF 1 | Oligodeoxynucleotide inhibition of Toll-like receptors 3, 7, 8, and 9 suppresses cytokine production in a human rheumatoid arthritis model. Eur J Immunol. 2016 Mar;46(3):772-81. |
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