Drug Information
Drug General Information | Top | |||
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Drug ID |
D4RD0C
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Drug Name |
Bamosiran
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Synonyms |
SYL040012
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Drug Type |
Small interfering RNA
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Indication | Glaucoma/ocular hypertension [ICD-11: 9C61] | Phase 2 | [1] | |
Company |
Sylentis
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Target and Pathway | Top | |||
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Target(s) | ADRB2 messenger RNA (ADRB2 mRNA) | Target Info | Inhibitor | [2] |
KEGG Pathway | Calcium signaling pathway | |||
cGMP-PKG signaling pathway | ||||
cAMP signaling pathway | ||||
Neuroactive ligand-receptor interaction | ||||
Endocytosis | ||||
Adrenergic signaling in cardiomyocytes | ||||
Salivary secretion | ||||
NetPath Pathway | TCR Signaling Pathway | |||
Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
Beta2 adrenergic receptor signaling pathway | ||||
Pathway Interaction Database | Arf6 trafficking events | |||
Arf6 signaling events | ||||
Reactome | Adrenoceptors | |||
G alpha (s) signalling events | ||||
WikiPathways | Monoamine GPCRs | |||
Calcium Regulation in the Cardiac Cell | ||||
GPCRs, Class A Rhodopsin-like | ||||
GPCR ligand binding | ||||
GPCR downstream signaling | ||||
GPCRs, Other |
References | Top | |||
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REF 1 | ClinicalTrials.gov (NCT02250612) SYL040012, Treatment for Open Angle Glaucoma (SYLTAG). U.S. National Institutes of Health. | |||
REF 2 | Clinical pipeline report, company report or official report of Sylentis. |
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