Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D4NGM6
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| Drug Name |
JNJ-75229414
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| Synonyms |
JNJ-9414
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| Drug Type |
CAR-T cell therapy
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| Indication | Prostate cancer [ICD-11: 2C82.0; ICD-9: 185] | Phase 1 | [1] | |
| Company |
Janssen Research & Development Raritan, NJ
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Tissue kallikrein (KLK2) | Target Info | . | [1] |
| KEGG Pathway | Endocrine and other factor-regulated calcium reabsorption | |||
| NetPath Pathway | IL2 Signaling Pathway | |||
| Pathway Interaction Database | Coregulation of Androgen receptor activity | |||
| Regulation of Androgen receptor activity | ||||
| Reactome | Activation of Matrix Metalloproteinases | |||
| Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | ||||
| Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | ||||
| WikiPathways | Prostate Cancer | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT05022849) A Phase 1, Dose Escalation Study of JNJ-75229414, a Chimeric Antigen Receptor T Cell (CAR-T) Therapy Directed Against KLK2 for Metastatic Castration-Resistant Prostate Cancer. U.S.National Institutes of Health. | |||
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