Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D4JV0H
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| Drug Name |
ASP1948
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| Synonyms |
PTZ-329
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| Drug Type |
Antibody
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| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C00-D48; ICD-9: 140-199] | Phase 1 | [1] | |
| Company |
Astellas Pharma; Potenza Therapeutics
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Neuropilin-1 (NRP1) | Target Info | Inhibitor | [2] |
| KEGG Pathway | Axon guidance | |||
| HTLV-I infection | ||||
| Panther Pathway | Axon guidance mediated by semaphorins | |||
| Pathway Interaction Database | VEGF and VEGFR signaling network | |||
| Plexin-D1 Signaling | ||||
| VEGFR1 specific signals | ||||
| Reactome | Neurophilin interactions with VEGF and VEGFR | |||
| CRMPs in Sema3A signaling | ||||
| CHL1 interactions | ||||
| WikiPathways | miR-targeted genes in squamous cell - TarBase | |||
| miR-targeted genes in muscle cell - TarBase | ||||
| miR-targeted genes in lymphocytes - TarBase | ||||
| miR-targeted genes in epithelium - TarBase | ||||
| Signaling by VEGF | ||||
| Semaphorin interactions | ||||
| L1CAM interactions | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT04094506) Study of ASP1948, Targeting an Immune Modulatory Receptor, in Japanese Patients With Advanced Solid Tumors. U.S. National Institutes of Health. | |||
| REF 2 | National Cancer Institute Drug Dictionary (drug name ASP1948). | |||
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