Drug Information
Drug General Information | Top | |||
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Drug ID |
D1PYC8
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Drug Name |
MGD019
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Drug Type |
Antibody
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Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C00-D48; ICD-9: 140-199] | Phase 1 | [1] | |
Company |
MacroGenics
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Target and Pathway | Top | |||
---|---|---|---|---|
Target(s) | Cytotoxic T-lymphocyte protein 4 (CTLA-4) | Target Info | Inhibitor | [2] |
Programmed cell death protein 1 (PD-1) | Target Info | Inhibitor | [2] | |
KEGG Pathway | Cell adhesion molecules (CAMs) | |||
T cell receptor signaling pathway | ||||
Autoimmune thyroid disease | ||||
Rheumatoid arthritis | ||||
Pathway Interaction Database | Calcineurin-regulated NFAT-dependent transcription in lymphocytes | |||
Reactome | CTLA4 inhibitory signaling | |||
PD-1 signaling | ||||
WikiPathways | Vitamin D Receptor Pathway | |||
T-Cell Receptor and Co-stimulatory Signaling | ||||
Allograft Rejection | ||||
Costimulation by the CD28 family |
References | Top | |||
---|---|---|---|---|
REF 1 | ClinicalTrials.gov (NCT03761017) MGD019 DART Protein in Unresectable/Metastatic Cancer. U.S. National Institutes of Health. | |||
REF 2 | Development and Preliminary Clinical Activity of PD-1-Guided CTLA-4 Blocking Bispecific DART Molecule. Cell Rep Med. 2020 Dec 22;1(9):100163. |
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