Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D18QIB
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| Drug Name |
MSC110
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| Synonyms |
Lacnotuzumab
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|
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| Drug Type |
Antibody
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| Indication | Pigmented villonodular synovitis [ICD-11: FA27.1; ICD-10: M12.2] | Phase 1 | [1] | |
| Company |
Novartis
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Macrophage colony-stimulating factor 1 (CSF1) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Ras signaling pathway | |||
| Rap1 signaling pathway | ||||
| Cytokine-cytokine receptor interaction | ||||
| PI3K-Akt signaling pathway | ||||
| Osteoclast differentiation | ||||
| Hematopoietic cell lineage | ||||
| TNF signaling pathway | ||||
| Rheumatoid arthritis | ||||
| NetPath Pathway | TSH Signaling Pathway | |||
| IL2 Signaling Pathway | ||||
| EGFR1 Signaling Pathway | ||||
| TGF_beta_Receptor Signaling Pathway | ||||
| Pathway Interaction Database | Signaling events mediated by PTP1B | |||
| Signaling events mediated by TCPTP | ||||
| Integrins in angiogenesis | ||||
| WikiPathways | Cytokines and Inflammatory Response | |||
| Hematopoietic Stem Cell Differentiation | ||||
| Differentiation Pathway | ||||
| miR-targeted genes in muscle cell - TarBase | ||||
| Folate Metabolism | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Colony-Stimulating Factor-1 Antibody Lacnotuzumab in a Phase 1 Healthy Volunteer Study and Mechanistic Investigation of Safety Outcomes. J Pharmacol Exp Ther. 2019 Jun;369(3):428-442. | |||
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