Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0ZU6O
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| Former ID |
DNC001401
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| Drug Name |
T-1106
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| Synonyms |
AC1NRS1H; T-1106; SCHEMBL6384698; CHEMBL261459; XVXWUBIIHFDOJO-KQYNXXCUSA-N; 4-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-3-oxopyrazine-2-carboxamide; 4-((2R,3R,4S,5R)-3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-3-oxo-3,4-dihydro-pyrazine-2-carboxylic acid amide; 4-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]-3-oxo-3,4-dihydro-2-pyrazinecarboxamide
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| Drug Type |
Small molecular drug
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| Indication | Virus infection [ICD-11: 1A24-1D9Z] | Investigative | [1], [2], [3] | |
| Structure |
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Download2D MOL |
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| Formula |
C10H13N3O6
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| Canonical SMILES |
C1=CN(C(=O)C(=N1)C(=O)N)C2C(C(C(O2)CO)O)O
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| InChI |
1S/C10H13N3O6/c11-8(17)5-9(18)13(2-1-12-5)10-7(16)6(15)4(3-14)19-10/h1-2,4,6-7,10,14-16H,3H2,(H2,11,17)/t4-,6-,7-,10-/m1/s1
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| InChIKey |
XVXWUBIIHFDOJO-KQYNXXCUSA-N
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| PubChem Compound ID | ||||
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Virus RNA-dependent RNA polymerase (Viru RdRP) | Target Info | Inhibitor | [1], [2], [3] |
| References | Top | |||
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| REF 1 | Activity of T-705 in a hamster model of yellow fever virus infection in comparison with that of a chemically related compound, T-1106. Antimicrob Agents Chemother. 2009 Jan;53(1):202-9. | |||
| REF 2 | PA subunit of RNA polymerase as a promising target for anti-influenza virus agents. Antiviral Res. 2008 Jun;78(3):194-201. | |||
| REF 3 | Antiviral agents active against influenza A viruses. Nat Rev Drug Discov. 2006 Dec;5(12):1015-25. | |||
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