Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0ZT0G
|
|||
| Former ID |
DNC000434
|
|||
| Drug Name |
Cinaciguat
|
|||
| Synonyms |
Cinaciguat; 329773-35-5; BAY 58-2667; BAY582667; UNII-59K0Y58UAD; BAY-58-2667; 59K0Y58UAD; 4-({(4-carboxybutyl)[2-(2-{[4-(2-phenylethyl)benzyl]oxy}phenyl)ethyl]amino}methyl)benzoic acid; Cinaciguat [INN:JAN]; cinaciguatum; Z90; Cinaciguat (JAN/INN); SCHEMBL249267; GTPL5168; CHEMBL1236936; QCR-279; Cinaciguat (BAY 58-2667); MolPort-039-139-611; CHEBI:142433; ZINC3934935; BCP07942; 3550AH; AKOS026750293; AN-1845; CS-1169; HY-14181; KB-40005; AB0095741; D07577; W-5794
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Acute decompensated heart failure [ICD-11: BD1Z; ICD-10: I50, I50.9; ICD-9: 428] | Phase 2 | [1], [2] | |
| Structure |
 |
Download2D MOL |
||
| Formula |
C36H39NO5
|
|||
| Canonical SMILES |
C1=CC=C(C=C1)CCC2=CC=C(C=C2)COC3=CC=CC=C3CCN(CCCCC(=O)O)CC4=CC=C(C=C4)C(=O)O
|
|||
| InChI |
1S/C36H39NO5/c38-35(39)12-6-7-24-37(26-30-19-21-33(22-20-30)36(40)41)25-23-32-10-4-5-11-34(32)42-27-31-17-15-29(16-18-31)14-13-28-8-2-1-3-9-28/h1-5,8-11,15-22H,6-7,12-14,23-27H2,(H,38,39)(H,40,41)
|
|||
| InChIKey |
WPYWMXNXEZFMAK-UHFFFAOYSA-N
|
|||
| CAS Number |
CAS 329773-35-5
|
|||
| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| ChEBI ID |
CHEBI:142433
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Guanylate cyclase soluble beta-1 (GUCY1B1) | Target Info | Activator | [3] |
| KEGG Pathway | Purine metabolism | |||
| cGMP-PKG signaling pathway | ||||
| Vascular smooth muscle contraction | ||||
| Gap junction | ||||
| Platelet activation | ||||
| Circadian entrainment | ||||
| Long-term depression | ||||
| Oxytocin signaling pathway | ||||
| Salivary secretion | ||||
| NetPath Pathway | TCR Signaling Pathway | |||
| IL4 Signaling Pathway | ||||
| Panther Pathway | Endothelin signaling pathway | |||
| Pathwhiz Pathway | Purine Metabolism | |||
| Reactome | Nitric oxide stimulates guanylate cyclase | |||
| WikiPathways | Platelet homeostasis | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5168). | |||
| REF 2 | ClinicalTrials.gov (NCT00559650) Placebo Controlled, Randomized, Double-blind, Multi-center Study to Investigate the Efficacy and Tolerability of BAY58-2667. U.S. National Institutes of Health. | |||
| REF 3 | Cinaciguat (BAY 58-2667) improves cardiopulmonary hemodynamics in patients with acute decompensated heart failure. Circulation. 2009 Jun 2;119(21):2781-8. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.