Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0ZE5U
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| Drug Name |
Indolinone derivative 1
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| Synonyms |
PMID25684022-Compound-US200607105563
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| Drug Type |
Small molecular drug
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| Indication | Metastatic cancer [ICD-11: 2D50-2E2Z] | Patented | [1] | |
| Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C76-C80; ICD-9: 140-229] | Patented | [1] | ||
| Company |
Schering AG
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| Structure |
 |
Download2D MOL |
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| Formula |
C15H14N4O2
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| Canonical SMILES |
CC(=C1C2=C(C=CC(=C2)NC(=O)N)NC1=O)C3=CC=CN3
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| InChI |
1S/C15H14N4O2/c1-8(11-3-2-6-17-11)13-10-7-9(18-15(16)21)4-5-12(10)19-14(13)20/h2-7,17H,1H3,(H,19,20)(H3,16,18,21)/b13-8-
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| InChIKey |
DFURSNCTQGJRRX-JYRVWZFOSA-N
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| CAS Number |
CAS 946843-63-6
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Pyruvate dehydrogenase kinase 1 (PDHK1) | Target Info | Inhibitor | [1] |
| Target's Patent Info | Pyruvate dehydrogenase kinase 1 (PDHK1) | Target's Patent Info | [1] | |
| KEGG Pathway | HIF-1 signaling pathway | |||
| Axon guidance | ||||
| Central carbon metabolism in cancer | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. | |||
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