Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0Z9EO
|
|||
| Former ID |
DNCL002890
|
|||
| Drug Name |
Metreleptin
|
|||
| Indication | Diabetic complication [ICD-11: 5A2Y] | Approved | [1], [2] | |
| Company |
Amylin Pharmaceuticals
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Leptin receptor (LEPR) | Target Info | Modulator | [3] |
| KEGG Pathway | Cytokine-cytokine receptor interaction | |||
| Neuroactive ligand-receptor interaction | ||||
| AMPK signaling pathway | ||||
| Jak-STAT signaling pathway | ||||
| Adipocytokine signaling pathway | ||||
| Non-alcoholic fatty liver disease (NAFLD) | ||||
| Pathway Interaction Database | Signaling events mediated by PTP1B | |||
| WikiPathways | Leptin signaling pathway | |||
| AMPK Signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7333). | |||
| REF 2 | US FDA approves orphan drug MYALEPT (metreleptin for injection) | |||
| REF 3 | 2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81. | |||
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