Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0Z6VR
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| Former ID |
DNC000357
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| Drug Name |
Buthionine sulfoximine
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| Synonyms |
AC1MS6SH
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| Drug Type |
Small molecular drug
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| Indication | Malaria [ICD-11: 1F40-1F45] | Investigative | [1] | |
| Solid tumour/cancer [ICD-11: 2A00-2F9Z] | Investigative | [1] | ||
| Structure |
 |
Download2D MOL |
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| Formula |
C8H18N2O3S
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| Canonical SMILES |
CCCCS(=N)(=O)CCC(C(=O)O)N
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| InChI |
1S/C8H18N2O3S/c1-2-3-5-14(10,13)6-4-7(9)8(11)12/h7,10H,2-6,9H2,1H3,(H,11,12)
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| InChIKey |
KJQFBVYMGADDTQ-UHFFFAOYSA-N
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| CAS Number |
CAS 5072-26-4
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| ChEBI ID |
CHEBI:28714
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Glutamate--cysteine ligase modifier (GCLM) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Glutathione metabolism | |||
| Metabolic pathways | ||||
| Pathwhiz Pathway | Glutamate Metabolism | |||
| Glutathione Metabolism | ||||
| Cysteine Metabolism | ||||
| WikiPathways | Transcriptional activation by NRF2 | |||
| NRF2 pathway | ||||
| Nuclear Receptors Meta-Pathway | ||||
| Metabolism of amino acids and derivatives | ||||
| Trans-sulfuration and one carbon metabolism | ||||
| Trans-sulfuration pathway | ||||
| Phase II conjugation | ||||
| Glutathione metabolism | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Novel molecular targets for antimalarial chemotherapy. Int J Antimicrob Agents. 2007 Jul;30(1):4-10. | |||
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