Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0Z5VG
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| Former ID |
DIB012502
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| Drug Name |
CZ-48
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| Synonyms |
Camptothecin-20-O-propionate; UNII-4S145C552U; CZ-48; 194414-69-2; 4S145C552U; SF 6A; CZ48; Camptothecin-20(S)-O-propionate; CZ 48; SCHEMBL1618775; CHEMBL124162; DTXSID30173074; 1H-Pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione, 4-ethyl-4-(1-oxopropoxy)-, (S)-
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| Drug Type |
Small molecular drug
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| Indication | Lymphoma [ICD-11: 2A80-2A86; ICD-9: 202.8, 208.9] | Phase 1 | [1] | |
| Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C00-D48; ICD-9: 140-199, 210-229] | Phase 1 | [1] | ||
| Structure |
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Download2D MOL |
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| Formula |
C23H20N2O5
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| Canonical SMILES |
CCC(=O)OC1(C2=C(COC1=O)C(=O)N3CC4=CC5=CC=CC=C5N=C4C3=C2)CC
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| InChI |
1S/C23H20N2O5/c1-3-19(26)30-23(4-2)16-10-18-20-14(9-13-7-5-6-8-17(13)24-20)11-25(18)21(27)15(16)12-29-22(23)28/h5-10H,3-4,11-12H2,1-2H3/t23-/m0/s1
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| InChIKey |
YCNIQYLWIPCLNY-QHCPKHFHSA-N
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| CAS Number |
CAS 194414-69-2
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | DNA topoisomerase I (TOP1) | Target Info | Inhibitor | [2] |
| NetPath Pathway | IL2 Signaling Pathway | |||
| Panther Pathway | DNA replication | |||
| Pathway Interaction Database | Caspase Cascade in Apoptosis | |||
| WikiPathways | Integrated Pancreatic Cancer Pathway | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
| REF 2 | Pharmacology of camptothecin esters. Ann N Y Acad Sci. 2000;922:216-23. | |||
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