Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0Z5DM
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| Former ID |
DIB012862
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| Drug Name |
IMD-0354
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| Synonyms |
IMD-2560; IMD-2560); I-kappaB kinase beta inhibitor (dermatological, atopic dermatitis/acne), Institute of Medicinal MolecularDesign; I-kappaB kinase beta inhibitor (oral, rheumatoid arthritis/osteoporosis), IMMD; IKK-beta inhibitor (dermatological, atopic dermatitis/acne), IMMD; IL-6 release inhibitor (oral, rheumatoid arthritis/osteoporosis), IMMD
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| Drug Type |
Small molecular drug
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| Indication | Acne vulgaris [ICD-11: ED80; ICD-10: L70.0; ICD-9: 706.1] | Phase 1 | [1] | |
| Company |
Institute of Medicinal Molecular Design Inc
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| Structure |
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Download2D MOL |
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| Formula |
C15H8ClF6NO2
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| Canonical SMILES |
C1=CC(=C(C=C1Cl)C(=O)NC2=CC(=CC(=C2)C(F)(F)F)C(F)(F)F)O
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| InChI |
1S/C15H8ClF6NO2/c16-9-1-2-12(24)11(6-9)13(25)23-10-4-7(14(17,18)19)3-8(5-10)15(20,21)22/h1-6,24H,(H,23,25)
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| InChIKey |
CHILCFMQWMQVAL-UHFFFAOYSA-N
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| CAS Number |
CAS 978-62-1
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:93310
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| References | Top | |||
|---|---|---|---|---|
| REF 1 | Activation of histamine H4 receptor inhibits TNFalpha/IMD-0354-induced apoptosis in human salivary NS-SV-AC cells. Apoptosis. 2014 Dec;19(12):1702-11. | |||
| REF 2 | I B kinase beta inhibitor IMD-0354 suppresses airway remodelling in a Dermatophagoides pteronyssinus-sensitized mouse model of chronic asthma. Clin Exp Allergy. 2011 Jan;41(1):104-15. | |||
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