Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0Z4VA
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| Former ID |
DIB010019
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| Drug Name |
UD-CG-212
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| Synonyms |
UD-CG-212BS; UD-CG-212Cl
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| Indication | Heart failure [ICD-11: BD10-BD13; ICD-10: I50, I50.9; ICD-9: 428] | Terminated | [1] | |
| Company |
Boehringer Ingelheim Corp
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| Structure |
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Download2D MOL |
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| Formula |
C18H16N4O2
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| Canonical SMILES |
CC1CC(=O)NN=C1C2=CC3=C(C=C2)N=C(N3)C4=CC=C(C=C4)O
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| InChI |
1S/C18H16N4O2/c1-10-8-16(24)21-22-17(10)12-4-7-14-15(9-12)20-18(19-14)11-2-5-13(23)6-3-11/h2-7,9-10,23H,8H2,1H3,(H,19,20)(H,21,24)
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| InChIKey |
QOAXSEARPHDXFC-UHFFFAOYSA-N
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| CAS Number |
CAS 108381-22-2
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Phosphodiesterase 3 (PDE3) | Target Info | Modulator | [2], [3] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Electrophysiological actions of the pimobendan metabolite, UD-CG 212 Cl, in guinea pig myocardium. J Pharmacol Exp Ther. 1992 Jan;260(1):58-63. | |||
| REF 2 | Phosphodiesterase inhibition in ventricular cardiomyocytes from guinea-pig hearts. Br J Pharmacol. 1992 Sep;107(1):127-33. | |||
| REF 3 | Contribution of cAMP-phosphodiesterase inhibition and sensitization of the contractile proteins for calcium to the inotropic effect of pimobendan i... Circ Res. 1991 Mar;68(3):689-701. | |||
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