Drug Information
Drug General Information | Top | |||
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Drug ID |
D0Z3NE
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Former ID |
DIB019552
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Drug Name |
PMID24099220C5i
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Synonyms |
GNF-PF-3777; tryptanthrin 5i; 8-Nitrotryptanthrin; AC1L9YX7; Oprea1_383200; Oprea1_416302; GTPL8223; GTPL10126; CTK5I3547; ZINC334588; BCP26220; BDBM50442991; AKOS032945018; CS-6001; HY-100687; 77603-42-0
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL
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Formula |
C15H7N3O4
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Canonical SMILES |
C1=CC=C2C(=C1)C(=O)N3C4=C(C=C(C=C4)[N+](=O)[O-])C(=O)C3=N2
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InChI |
1S/C15H7N3O4/c19-13-10-7-8(18(21)22)5-6-12(10)17-14(13)16-11-4-2-1-3-9(11)15(17)20/h1-7H
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InChIKey |
UFMQJYHLIUACCG-UHFFFAOYSA-N
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PubChem Compound ID | ||||
PubChem Substance ID |
Target and Pathway | Top | |||
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Target(s) | Indoleamine 2,3-dioxygenase 1 (IDO1) | Target Info | Inhibitor | [1] |
BioCyc | Superpathway of tryptophan utilization | |||
Tryptophan degradation | ||||
L-kynurenine degradation | ||||
Tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde | ||||
NAD de novo biosynthesis | ||||
KEGG Pathway | Tryptophan metabolism | |||
Metabolic pathways | ||||
African trypanosomiasis | ||||
NetPath Pathway | TSLP Signaling Pathway | |||
IL5 Signaling Pathway | ||||
TGF_beta_Receptor Signaling Pathway | ||||
Pathwhiz Pathway | Tryptophan Metabolism | |||
Reactome | Tryptophan catabolism | |||
WikiPathways | Tryptophan metabolism | |||
Metabolism of amino acids and derivatives |
References | Top | |||
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REF 1 | Discovery of tryptanthrin derivatives as potent inhibitors of indoleamine 2,3-dioxygenase with therapeutic activity in Lewis lung cancer (LLC) tumor-bearing mice. J Med Chem. 2013 Nov 14;56(21):8321-31. |
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