Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0Z2SL
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| Former ID |
DNC001379
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| Drug Name |
Stachyflin
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| Synonyms |
Stachyflin; dihydroxy(tetramethyl)[ ]one; (+)-Stachyflin; AC1LAQMJ; 3H-Naphtho[1',8a':5,6]pyrano[2,3-e]isoindol-3-one, 1,2,6,6a,7,8,9,9a,10,11,12,13-dodecahydro-5,11-dihydroxy-6a,7,10,10-tetramethyl-, (6aR,7S,9aS,11S,13aS)-
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1], [2], [3], [4] | |
| Structure |
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Download2D MOL |
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| Formula |
C23H31NO4
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| Canonical SMILES |
CC1CCC2C(C(CCC23C1(CC4=C(C=C5C(=C4O3)CNC5=O)O)C)O)(C)C
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| InChI |
1S/C23H31NO4/c1-12-5-6-17-21(2,3)18(26)7-8-23(17)22(12,4)10-14-16(25)9-13-15(19(14)28-23)11-24-20(13)27/h9,12,17-18,25-26H,5-8,10-11H2,1-4H3,(H,24,27)/t12-,17-,18-,22+,23-/m0/s1
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| InChIKey |
KUWCILGWLAWLGB-SFJHCMNLSA-N
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Influenza Hemagglutinin (Influ HA) | Target Info | Inhibitor | [1], [2], [3], [4] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Structure of influenza hemagglutinin in complex with an inhibitor of membrane fusion. Proc Natl Acad Sci U S A. 2008 Nov 18;105(46):17736-41. | |||
| REF 2 | Novel stachyflin derivatives from Stachybotrys sp. RF-7260. Fermentation, isolation, structure elucidation and biological activities. J Antibiot (Tokyo). 2002 Mar;55(3):239-48. | |||
| REF 3 | An approach to the identification of potent inhibitors of influenza virus fusion using parallel synthesis methodology. Bioorg Med Chem Lett. 2001 Sep 3;11(17):2393-6. | |||
| REF 4 | Inhibition of influenza A virus replication by compounds interfering with the fusogenic function of the viral hemagglutinin. J Virol. 1999 Jan;73(1):140-51. | |||
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