Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0YZ8I
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| Former ID |
DNC000831
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| Drug Name |
JWH-015
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| Synonyms |
JWH-015; 155471-08-2; JWH 015; UNII-W4FL204T10; (2-Methyl-1-propyl-1H-indol-3-yl)-1-naphthalenylmethanone; JWH015; (2-methyl-1-propylindol-3-yl)-naphthalen-1-ylmethanone; CHEMBL306764; W4FL204T10; MFCD02094630; (2-methyl-1-propyl-1H-indol-3-yl)(naphthalen-1-yl)methanone; JHW 015; SR-01000597570; (2-Methyl-1-propylindol-3-yl)(naphthalen-1-yl)methanone; NCGC00025117-01; Tocris-1341; PubChem19328; MLS002153392; SCHEMBL497044; GTPL5558; AC1N784D; BDBM21282; CHEBI:92318; DTXSID60165902; AOB5643; MolPort-003-983-602
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| Drug Type |
Small molecular drug
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| Indication | Organ transplant rejection [ICD-11: NE84; ICD-9: 279.5, 996] | Patented | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C23H21NO
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| Canonical SMILES |
CCCN1C(=C(C2=CC=CC=C21)C(=O)C3=CC=CC4=CC=CC=C43)C
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| InChI |
1S/C23H21NO/c1-3-15-24-16(2)22(20-12-6-7-14-21(20)24)23(25)19-13-8-10-17-9-4-5-11-18(17)19/h4-14H,3,15H2,1-2H3
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| InChIKey |
LJSBBBWQTLXQEN-UHFFFAOYSA-N
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| CAS Number |
CAS 155471-08-2
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| PubChem Compound ID | ||||
| PubChem Substance ID |
6274360, 9624193, 11114036, 14875077, 24278502, 49689354, 56463190, 57309607, 57356879, 71754794, 79509496, 85788648, 91746339, 103274236, 112818142, 124801407, 125335445, 128498955, 134339061, 134340148, 135260952, 135289033, 135368331, 135698395, 137103971, 142472542, 143494080, 152048721, 152237521, 162023061, 162249344, 164761410, 165238056, 170481101, 175608137, 178102197, 178126927, 179337480, 184597693, 198973429, 226812352, 241182343, 250120982, 252451159, 252457923
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| ChEBI ID |
CHEBI:92318
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Cannabinoid receptor 2 (CB2) | Target Info | Agonist | [1], [2] |
| Target's Patent Info | Cannabinoid receptor 2 (CB2) | Target's Patent Info | [1], [2] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Reactome | Class A/1 (Rhodopsin-like receptors) | |||
| G alpha (i) signalling events | ||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | |||
| Small Ligand GPCRs | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Cannabinoid receptor 2 (CB2) agonists and antagonists: a patent update.Expert Opin Ther Pat. 2016 Jul;26(7):843-56. | |||
| REF 2 | Posttraining activation of CB1 cannabinoid receptors in the CA1 region of the dorsal hippocampus impairs object recognition long-term memory. Neurobiol Learn Mem. 2008 Sep;90(2):374-81. | |||
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