Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0YH8F
|
|||
| Former ID |
DNCL002352
|
|||
| Drug Name |
RG7347
|
|||
| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C00-D48; ICD-9: 140-199, 210-229] | Phase 1 | [1] | |
| Company |
Genentech; Roche
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Neuropilin-1 (NRP1) | Target Info | Modulator | [2] |
| KEGG Pathway | Axon guidance | |||
| HTLV-I infection | ||||
| Panther Pathway | Axon guidance mediated by semaphorins | |||
| Pathway Interaction Database | VEGF and VEGFR signaling network | |||
| Plexin-D1 Signaling | ||||
| VEGFR1 specific signals | ||||
| Reactome | Neurophilin interactions with VEGF and VEGFR | |||
| CRMPs in Sema3A signaling | ||||
| CHL1 interactions | ||||
| WikiPathways | miR-targeted genes in squamous cell - TarBase | |||
| miR-targeted genes in muscle cell - TarBase | ||||
| miR-targeted genes in lymphocytes - TarBase | ||||
| miR-targeted genes in epithelium - TarBase | ||||
| Signaling by VEGF | ||||
| Semaphorin interactions | ||||
| L1CAM interactions | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027393) | |||
| REF 2 | Neuropilin-1 as Therapeutic Target for Malignant Melanoma. Front Oncol. 2015; 5: 125. | |||
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