Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0YA9Z
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| Former ID |
DAP000432
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| Drug Name |
Ampicillin
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| Synonyms |
ABPC; Acillin; Adobacillin; Alpen; Amblosin; Amcill; Amfipen; Aminobenzylpenicillin; Ampen; Ampichel; Ampicil; Ampicilina; Ampicillanyl; Ampicillina; Ampicilline; Ampicillinum; Ampicin; Ampifarm; Ampikel; Ampimed; Ampipenin; Ampiscel; Ampisyn; Ampivax; Ampivet; Amplacilina; Amplin; Amplipenyl; Amplisom; Amplital; Austrapen; Binotal; Bonapicillin; Britacil; Campicillin; Cimex; Copharcilin; Delcillin; Deripen; Divercillin; Doktacillin; Duphacillin; Grampenil; Guicitrina; Guicitrine; Lifeampil; Morepen; Norobrittin; Nuvapen; Omnipen; Orbicilina; Penbristol; Penbritin; Penbrock; Penicline; Penimic; Pensyn; Pentrex; Pentrexl; Pentrexyl; Polycillin; Ponecil; Princillin; Principen; QIDamp; Racenacillin; Rosampline;Roscillin; Semicillin; Servicillin; Sumipanto; Supen; Synpenin; Texcillin; Tokiocillin; Tolomol; Totacillin; Totalciclina; Totapen; Trifacilina; Ukapen; Ultrabion; Ultrabron; Vampen; Viccillin; Wypicil; Amfipen V; Amipenix S; Ampicillin A; Ampicillin Anhydrous; Ampicillin Base; Ampicillin acid; Ampicillin anhydrate; Ampicillina [DCIT]; Anhydrous ampicillin; Olin Kid; Pen A; Pen A Oral; Pen Ampil;Penbritin paediatric; Penbritin syrup; Pfizerpen A; Semicillin R; Viccillin S; AY 6108; BA 7305; BRL 1341; Bayer 5427; HI 63; P 50; Principen 125; Principen 250; Principen 500; SQ 17382; AB-PC; AB-PCSol; AY-6108; Ambidrin (TN); Ampi-Co; Ampi-Tab; Ampi-bol; Ampicilina [INN-Spanish]; Ampicilline [INN-French]; Ampicillinum [INN-Latin]; Ampipenin, nt3; Ampy-Penyl; Anhydrous ampicillin (JP15); BRL-1341; D-Ampicillin; D-Cillin; KS-R1; Novo-ampicillin; OMNIPEN (AMPICILLIN); Omnipen (TN); Omnipen-N; P-50; Penbritin-S; Penicillin, Aminobenzyl; Pfizerpen-A; Polycillin-N; Polyflex (Veterinary); Ro-Ampen; SK-Ampicillin; Totacillin (sodium); Totacillin-N; WY-5103; Ampicillin (USP/INN); AMPICILLIN (SEE ALSO AMPICILLIN TRIHYDRATE 7177-48-2); Ampicillin [USAN:BAN:INN:JAN]; Ampicillin [USAN:INN:BAN:JAN];D-(-)-Ampicillin; D-(-)-alpha-Aminobenzylpenicillin; D-(-)-alpha-Aminopenicillin; D-(-)-6-(alpha-Aminophenylacetamido)penicillanic acid; 6-(D(-)-alpha-Aminophenylacetamido)penicillanic acid; 6beta-[(2R)-2-amino-2-phenylacetamido]-2,2-dimethylpenam-3alpha-carbonyl; 6beta-[(2R)-2-amino-2-phenylacetamido]-2,2-dimethylpenam-3alpha-carboxylic acid
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| Drug Type |
Small molecular drug
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| Indication | Bacterial infection [ICD-11: 1A00-1C4Z; ICD-10: A00-B99] | Approved | [1] | |
| Therapeutic Class |
Antibiotics
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| Company |
Stadapharm GmbH
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| Structure |
 |
Download2D MOL |
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| Formula |
C16H19N3O4S
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| Canonical SMILES |
CC1(C(N2C(S1)C(C2=O)NC(=O)C(C3=CC=CC=C3)N)C(=O)O)C
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| InChI |
1S/C16H19N3O4S/c1-16(2)11(15(22)23)19-13(21)10(14(19)24-16)18-12(20)9(17)8-6-4-3-5-7-8/h3-7,9-11,14H,17H2,1-2H3,(H,18,20)(H,22,23)/t9-,10-,11+,14-/m1/s1
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| InChIKey |
AVKUERGKIZMTKX-NJBDSQKTSA-N
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| CAS Number |
CAS 69-53-4
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| PubChem Compound ID | ||||
| PubChem Substance ID |
8803, 612819, 855874, 7847272, 7978702, 8153929, 11335641, 11360880, 11362844, 11365406, 11367968, 11371462, 11373737, 11376130, 11461852, 11466142, 11467262, 11484554, 11485803, 11488585, 11490117, 11491964, 11493864, 14802821, 14827659, 24891442, 26706523, 29215015, 29225245, 46392100, 46484751, 46505346, 47291088, 47440199, 47810705, 47885360, 47959687, 48035057, 48035058, 48184948, 48415562, 49698352, 49855717, 50064028, 50104132, 50930328, 53789146, 53801116, 56312591, 56314308
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| ChEBI ID |
CHEBI:28971
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| ADReCS Drug ID | BADD_D00133 ; BADD_D00134 ; BADD_D00135 | |||
| SuperDrug ATC ID |
J01CA01; S01AA19
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| SuperDrug CAS ID |
cas=000069534
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Abundace of Studied Microbe(s) Regulated by Drug | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacillales | ||||
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Studied Microbe: Paenibacillus
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | BALB/c mice | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Paenibacillus was increased after Ampicillin treatment at day 3 (p = 0.002). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
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Studied Microbe: Alistipes
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | C57BL/6 mice | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Alistipes was decreased by Ampicillin. | |||
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Studied Microbe: Bacteroides
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | C57BL/6 mice | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Bacteroides was decreased by Ampicillin. | |||
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Studied Microbe: Bacteroides
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[4] | |||
| Hierarchy | ||||
| Abundance Change | No significant change | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Bacteroides was not significantly changed by Ampicillin. | |||
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Studied Microbe: Bacteroides caccae
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides caccae was decreased by Ampicillin trihydrate (adjusted p-values: 1.40E-05). | |||
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Studied Microbe: Bacteroides fragilis nontoxigenic
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides fragilis nontoxigenic was decreased by Ampicillin trihydrate (adjusted p-values: 2.48E-03). | |||
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Studied Microbe: Bacteroides ovatus
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides ovatus was decreased by Ampicillin trihydrate (adjusted p-values: 4.28E-03). | |||
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Studied Microbe: Bacteroides uniformis
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides uniformis was decreased by Ampicillin trihydrate (adjusted p-values: 3.10E-05). | |||
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Studied Microbe: Bacteroides vulgatus
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides vulgatus was decreased by Ampicillin trihydrate (adjusted p-values: 1.97E-06). | |||
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Studied Microbe: Barnesiella
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | BALB/c mice | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Barnesiella was decreased after Ampicillin treatment at day 3 (p = 0.002). | |||
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Studied Microbe: Barnesiella
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | C57BL/6 mice | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Barnesiella was decreased by Ampicillin. | |||
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Studied Microbe: Odoribacter splanchnicus
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Odoribacter splanchnicus was decreased by Ampicillin trihydrate (adjusted p-values: 5.04E-06). | |||
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Studied Microbe: Parabacteroides distasonis
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Parabacteroides distasonis was decreased by Ampicillin trihydrate (adjusted p-values: 5.28E-06). | |||
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Studied Microbe: Parabacteroides merdae
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Parabacteroides merdae was decreased by Ampicillin trihydrate (adjusted p-values: 4.93E-07). | |||
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Studied Microbe: Porphyromonadaceae
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | C57BL/6 mice | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Porphyromonadaceae was decreased by Ampicillin. | |||
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Studied Microbe: Prevotella
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | BALB/c mice | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Prevotella was decreased after Ampicillin treatment at day 14 (p = 0.004). | |||
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Studied Microbe: Prevotella
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | BALB/c mice | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Prevotella was decreased after Ampicillin treatment at day 3 (p = 0.002). | |||
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Studied Microbe: Prevotella copri
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Prevotella copri was decreased by Ampicillin trihydrate (adjusted p-values: 3.54E-05). | |||
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Studied Microbe: unclassified Bacteroidales
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | BALB/c mice | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of unclassified Bacteroidales was decreased after Ampicillin treatment at day 3 (p = 0.002). | |||
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Studied Microbe: unclassified Porphyromonadaceae
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | BALB/c mice | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of unclassified Porphyromonadaceae was decreased after Ampicillin treatment at day 3 (p = 0.002). | |||
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Studied Microbe: unclassified Prevotellaceae
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | BALB/c mice | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of unclassified Prevotellaceae was decreased after Ampicillin treatment at day 14 (p = 0.002). | |||
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Studied Microbe: unclassified Prevotellaceae
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | BALB/c mice | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of unclassified Prevotellaceae was decreased after Ampicillin treatment at day 3 (p = 0.002). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bifidobacteriales | ||||
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Studied Microbe: Bifidobacterium
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|
[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | C57BL/6 mice | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Bifidobacterium was decreased by Ampicillin. | |||
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Studied Microbe: Bifidobacterium adolescentis
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|
[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bifidobacterium adolescentis was decreased by Ampicillin trihydrate (adjusted p-values: 5.04E-06). | |||
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Studied Microbe: Bifidobacterium longum
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|
[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bifidobacterium longum was decreased by Ampicillin trihydrate (adjusted p-values: 5.04E-06). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Campylobacterales | ||||
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Studied Microbe: Helicobacter
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | BALB/c mice | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Helicobacter was decreased after Ampicillin treatment at day 14 (p = 0.009). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Coriobacteriales | ||||
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Studied Microbe: Collinsella aerofaciens
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|
[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Collinsella aerofaciens was decreased by Ampicillin trihydrate (adjusted p-values: 2.73E-07). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eggerthellales | ||||
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Studied Microbe: Eggerthella lenta
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Eggerthella lenta was decreased by Ampicillin trihydrate (adjusted p-values: 5.30E-06). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Enterobacterales | ||||
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Studied Microbe: Escherichia
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | C57BL/6 mice | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Escherichia was increased by Ampicillin. | |||
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Studied Microbe: Escherichia
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[4] | |||
| Hierarchy | ||||
| Abundance Change | No significant change | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Escherichia was not significantly changed by Ampicillin. | |||
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Studied Microbe: Escherichia coli ED1a
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Escherichia coli ED1a was decreased by Ampicillin trihydrate (adjusted p-values: 8.27E-06). | |||
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Studied Microbe: Escherichia coli IAI1
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Escherichia coli IAI1 was decreased by Ampicillin trihydrate (adjusted p-values: 5.51E-07). | |||
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Studied Microbe: Escherichia/Shigella sp.
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | BALB/c mice | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Escherichia/Shigella sp. was increased after Ampicillin treatment at day 3 (p = 0.014). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Erysipelotrichales | ||||
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Studied Microbe: Erysipelatoclostridium ramosum
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Erysipelatoclostridium ramosum was decreased by Ampicillin trihydrate (adjusted p-values: 9.36E-06). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
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Studied Microbe: Blautia obeum
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Blautia obeum was decreased by Ampicillin trihydrate (adjusted p-values: 7.50E-07). | |||
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Studied Microbe: Clostridioides difficile
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Clostridioides difficile was decreased by Ampicillin trihydrate (adjusted p-values: 1.46E-05). | |||
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Studied Microbe: Clostridium
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | BALB/c mice | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Clostridium was increased after Ampicillin treatment at day 3 (p = 0.009). | |||
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Studied Microbe: Clostridium
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[4] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Clostridium was increased by Ampicillin. | |||
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Studied Microbe: Clostridium perfringens
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Clostridium perfringens was decreased by Ampicillin trihydrate (adjusted p-values: 5.51E-07). | |||
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Studied Microbe: Coprococcus comes
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Coprococcus comes was decreased by Ampicillin trihydrate (adjusted p-values: 8.88E-06). | |||
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Studied Microbe: Dorea formicigenerans
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Dorea formicigenerans was decreased by Ampicillin trihydrate (adjusted p-values: 2.38E-04). | |||
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Studied Microbe: Eubacterium eligens
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Eubacterium eligens was decreased by Ampicillin trihydrate (adjusted p-values: 7.44E-06). | |||
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Studied Microbe: Eubacterium rectale
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Eubacterium rectale was decreased by Ampicillin trihydrate (adjusted p-values: 3.62E-04). | |||
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Studied Microbe: Lacrimispora saccharolytica
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|
[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Lacrimispora saccharolytica was decreased by Ampicillin trihydrate (adjusted p-values: 4.14E-07). | |||
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Studied Microbe: Roseburia hominis
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Roseburia hominis was decreased by Ampicillin trihydrate (adjusted p-values: 3.74E-05). | |||
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Studied Microbe: Roseburia intestinalis
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Roseburia intestinalis was decreased by Ampicillin trihydrate (adjusted p-values: 1.39E-04). | |||
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Studied Microbe: Ruminococcus bromii
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Ruminococcus bromii was decreased by Ampicillin trihydrate (adjusted p-values: 9.10E-06). | |||
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Studied Microbe: Ruminococcus gnavus
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Ruminococcus gnavus was decreased by Ampicillin trihydrate (adjusted p-values: 6.75E-05). | |||
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Studied Microbe: Ruminococcus torques
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Ruminococcus torques was decreased by Ampicillin trihydrate (adjusted p-values: 6.57E-07). | |||
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Studied Microbe: unclassified Lachnospiraceae
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | BALB/c mice | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of unclassified Lachnospiraceae was increased after Ampicillin treatment at day 14 (p = 0.01). | |||
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Studied Microbe: unclassified Lachnospiraceae
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | BALB/c mice | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of unclassified Lachnospiraceae was decreased after Ampicillin treatment at day 3 (p = 0.002). | |||
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Studied Microbe: unclassified Oscillospiraceae
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | BALB/c mice | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of unclassified Oscillospiraceae was decreased after Ampicillin treatment at day 3 (p = 0.002). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Lactobacillales | ||||
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Studied Microbe: Enterococcus
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | BALB/c mice | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Enterococcus was increased after Ampicillin treatment at day 3 (p = 0.027). | |||
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Studied Microbe: Enterococcus
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|
[4] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Enterococcus was increased by Ampicillin. | |||
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Studied Microbe: Lactobacillus
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|
[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | C57BL/6 mice | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Lactobacillus was decreased by Ampicillin. | |||
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Studied Microbe: Lactobacillus
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|
[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Lactobacillus was decreased by Ampicillin. | |||
|
Studied Microbe: Lactobacillus paracasei
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Lactobacillus paracasei was decreased by Ampicillin trihydrate (adjusted p-values: 9.12E-07). | |||
|
Studied Microbe: Streptococcus
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | BALB/c mice | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Streptococcus was decreased after Ampicillin treatment at day 14 (p = 0.009). | |||
|
Studied Microbe: Streptococcus parasanguinis
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Streptococcus parasanguinis was decreased by Ampicillin trihydrate (adjusted p-values: 5.51E-07). | |||
|
Studied Microbe: Streptococcus salivarius
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Streptococcus salivarius was decreased by Ampicillin trihydrate (adjusted p-values: 5.72E-07). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Mycoplasmatales | ||||
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Studied Microbe: Mycoplasma
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | BALB/c mice | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Mycoplasma was increased after Ampicillin treatment at day 3 (p = 0.02). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Pseudomonadales | ||||
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Studied Microbe: Pseudomonas
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | C57BL/6 mice | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Pseudomonas was increased by Ampicillin. | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Veillonellales | ||||
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Studied Microbe: Veillonella parvula
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Veillonella parvula was decreased by Ampicillin trihydrate (adjusted p-values: 5.04E-06). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Verrucomicrobiales | ||||
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Studied Microbe: Akkermansia
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | BALB/c mice | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Akkermansia was decreased after Ampicillin treatment at day 3 (p = 0.004). | |||
|
Studied Microbe: Akkermansia
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | C57BL/6 mice | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Akkermansia was decreased by Ampicillin. | |||
|
Studied Microbe: Akkermansia muciniphila
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Akkermansia muciniphila was decreased by Ampicillin trihydrate (adjusted p-values: 1.80E-05). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Gut microbiota | ||||
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Studied Microbe: unclassified Bacteroidetes
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | BALB/c mice | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of unclassified Bacteroidetes was decreased after Ampicillin treatment at day 3 (p = 0.002). | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Bacterial Penicillin binding protein (Bact PBP) | Target Info | Binder | [6] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 061936. | |||
| REF 2 | Feeding bovine milks with low or high IgA levels is associated with altered re-establishment of murine intestinal microbiota after antibiotic treatment. PeerJ. 2016 Sep 29;4:e2518. | |||
| REF 3 | Antibiotic-Induced Alterations of the Murine Gut Microbiota and Subsequent Effects on Colonization Resistance against Clostridium difficile. mBio. 2015 Jul 14;6(4):e00974. | |||
| REF 4 | The influence of single dose intravenous antibiotics on faecal flora and emergence of Clostridium difficile. J Antimicrob Chemother. 1985 Mar;15(3):319-26. | |||
| REF 5 | Extensive impact of non-antibiotic drugs on human gut bacteria. Nature. 2018 Mar 29;555(7698):623-628. | |||
| REF 6 | Effects of amino acid alterations in penicillin-binding proteins (PBPs) 1a, 2b, and 2x on PBP affinities of penicillin, ampicillin, amoxicillin, cefditoren, cefuroxime, cefprozil, and cefaclor in 18 clinical isolates of penicillin-susceptible, -intermediate, and -resistant pneumococci. Antimicrob Agents Chemother. 2002 May;46(5):1273-80. | |||
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