Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0Y9PH
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| Former ID |
DNC010074
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| Drug Name |
Phenylacetyl-Arg-Val-Arg-4-amidinobenzylamide
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| Synonyms |
CHEMBL566340; phenylacetyl-Arg-Val-Arg-4-amidinobenzylamide; SCHEMBL7920067; GTPL6564; BDBM50303774
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C33H50N12O4
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| Canonical SMILES |
CC(C)C(C(=O)NC(CCCN=C(N)N)C(=O)NCC1=CC=C(C=C1)C(=N)N)NC(=O)C(CCCN=C(N)N)NC(=O)CC2=CC=CC=C2
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| InChI |
1S/C33H50N12O4/c1-20(2)27(45-30(48)25(11-7-17-41-33(38)39)43-26(46)18-21-8-4-3-5-9-21)31(49)44-24(10-6-16-40-32(36)37)29(47)42-19-22-12-14-23(15-13-22)28(34)35/h3-5,8-9,12-15,20,24-25,27H,6-7,10-11,16-19H2,1-2H3,(H3,34,35)(H,42,47)(H,43,46)(H,44,49)(H,45,48)(H4,36,37,40)(H4,38,39,41)/t24-,25-,27-/m0/s1
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| InChIKey |
YGMAIAXBJLVVLI-KLJDGLGGSA-N
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Neuroendocrine convertase 1 (PCSK1) | Target Info | Inhibitor | [2] |
| Neuroendocrine convertase 2 (PCSK2) | Target Info | Inhibitor | [2] | |
| Reactome | Insulin processing | |||
| WikiPathways | Insulin Processing | |||
| Incretin Synthesis, Secretion, and Inactivation | ||||
| Metabolism of amino acids and derivatives | ||||
| Peptide hormone biosynthesis | ||||
| Synthesis, Secretion, and Deacylation of Ghrelin | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6564). | |||
| REF 2 | Potent inhibitors of furin and furin-like proprotein convertases containing decarboxylated P1 arginine mimetics. J Med Chem. 2010 Feb 11;53(3):1067-75. | |||
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