Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0Y8AW
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| Former ID |
DNCL002489
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| Drug Name |
CB3304
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| Synonyms |
Noscapine
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| Drug Type |
Small molecular drug
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| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C76-C80; ICD-9: 140-229] | Phase 1/2 | [1] | |
| Company |
Cougar Biotechnology
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| Structure |
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Download2D MOL |
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| Formula |
C22H23NO7
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| Canonical SMILES |
CN1CCC2=CC3=C(C(=C2C1C4C5=C(C(=C(C=C5)OC)OC)C(=O)O4)OC)OCO3
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| InChI |
1S/C22H23NO7/c1-23-8-7-11-9-14-20(29-10-28-14)21(27-4)15(11)17(23)18-12-5-6-13(25-2)19(26-3)16(12)22(24)30-18/h5-6,9,17-18H,7-8,10H2,1-4H3/t17-,18+/m1/s1
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| InChIKey |
AKNNEGZIBPJZJG-MSOLQXFVSA-N
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| CAS Number |
CAS 6035-40-1
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| PubChem Compound ID | ||||
| PubChem Substance ID |
11783, 71491, 415752, 605271, 855860, 7848099, 7980174, 8065369, 9413073, 10321868, 11113349, 11193550, 11408713, 11466591, 11467711, 11486301, 14831210, 14904386, 17439397, 24862408, 41295460, 47216689, 47216690, 47365103, 48184909, 48184910, 48416344, 49645498, 49698554, 50104123, 50104124, 50104125, 53788781, 57400976, 57705206, 61055762, 75471156, 85787957, 87544097, 87982965, 90341457, 92125312, 92718085, 103462008, 103914348, 104826459, 113483048, 115354111, 118055360, 121362983
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| ChEBI ID |
CHEBI:73237
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| SuperDrug ATC ID |
R05DA07
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
|
Studied Microbe: Alistipes indistinctus DSM22520
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|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Noscapine can be metabolized by Alistipes indistinctus DSM22520 (log2FC = -0.378; p = 0.011). | |||
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Studied Microbe: Bacteroides dorei DSM 17855
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|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Noscapine can be metabolized by Bacteroides dorei DSM 17855 (log2FC = -0.405; p = 0.007). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Enterobacterales | ||||
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Studied Microbe: Providencia alcalifaciens DSM 30120
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|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Noscapine can be metabolized by Providencia alcalifaciens DSM 30120 (log2FC = -0.322; p = 0.003). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Erysipelotrichales | ||||
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Studied Microbe: Eubacterium biforme DSM 3989
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|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Noscapine can be metabolized by Eubacterium biforme DSM 3989 (log2FC = -0.458; p = 0.013). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
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Studied Microbe: Bryantia formatexigens DSM 14469
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|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Noscapine can be metabolized by Bryantia formatexigens DSM 14469 (log2FC = -0.457; p = 0.007). | |||
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Studied Microbe: Ruminococcus torques ATCC 27756
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Noscapine can be metabolized by Ruminococcus torques ATCC 27756 (log2FC = -0.338; p = 0.03). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Lactobacillales | ||||
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Studied Microbe: Lactobacillus reuteri CF48-3A
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|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Noscapine can be metabolized by Lactobacillus reuteri CF48-3A (log2FC = -0.343; p = 0.035). | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT00912899) A Study of Noscapine HCl (CB3304 ) in Patients With Relapsed or Refractory Multiple Myeloma. U.S. National Institutes of Health. | |||
| REF 2 | Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467. | |||
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