Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0Y7ZD
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| Former ID |
DNAP001377
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| Drug Name |
Aminolevulinic acid hci
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| Synonyms |
Aminolevulinic acid; 5-Aminolevulinic acid; 5-Amino-4-oxopentanoic acid; 106-60-5; 5-Aminolevulinate; delta-aminolevulinic acid; Pentanoic acid, 5-amino-4-oxo-; Aladerm; 5-Amino-4-oxovaleric acid; Kerastick; Ameluz; Aminolevulinate; 5-ALA; delta-ALA; 5-Amino-4-oxopentanoate; 5-amino-levulinate; 5-amino-levulinic acid; 5-amino-4-oxo-pentanoic acid; CCRIS 8958; UNII-88755TAZ87; EINECS 203-414-1; Levulinic acid, 5-amino-; CHEMBL601; 4-oxo-5-amino-pentanoic acid; CHEBI:17549; ZGXJTSGNIOSYLO-UHFFFAOYSA-N; 88755TAZ87; Levulan (TN)
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| Drug Type |
Small molecular drug
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| Indication | Acne vulgaris [ICD-11: ED80; ICD-10: L70.0; ICD-9: 706.1] | Approved | [1], [2] | |
| Actinic keratosis [ICD-11: EK90.0; ICD-10: L57.0; ICD-9: 702] | Approved | [3] | ||
| Structure |
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Download2D MOL |
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| Formula |
C5H9NO3
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| Canonical SMILES |
C(CC(=O)O)C(=O)CN
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| InChI |
1S/C5H9NO3/c6-3-4(7)1-2-5(8)9/h1-3,6H2,(H,8,9)
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| InChIKey |
ZGXJTSGNIOSYLO-UHFFFAOYSA-N
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| CAS Number |
CAS 106-60-5
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| PubChem Compound ID | ||||
| PubChem Substance ID |
3719, 841472, 5427092, 8144107, 8150474, 11342129, 11362312, 11364476, 11367038, 11369600, 11372726, 11374315, 11377762, 11485579, 11487714, 11489478, 11491469, 11492433, 11495396, 15170674, 24438516, 46506856, 47589325, 47662632, 50002793, 50122683, 51031867, 51091887, 53789366, 56320695, 56322917, 57319985, 85083671, 85291378, 92298402, 92712186, 93166418, 99451455, 103182993, 104098261, 104170099, 104293958, 108134724, 118693344, 121362447, 124799829, 125662954, 126523837, 126579879, 126630164
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| ChEBI ID |
CHEBI:17549
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| ADReCS Drug ID | BADD_D00110 | |||
| SuperDrug ATC ID |
L01XD04
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Delta-aminolevulinic acid dehydratase (ALAD) | Target Info | Inhibitor | [4], [5], [6] |
| BioCyc | Heme biosynthesis | |||
| Tetrapyrrole biosynthesis | ||||
| KEGG Pathway | Porphyrin and chlorophyll metabolism | |||
| Metabolic pathways | ||||
| Panther Pathway | Heme biosynthesis | |||
| Pathwhiz Pathway | Porphyrin Metabolism | |||
| WikiPathways | Heme Biosynthesis | |||
| Metabolism of porphyrins | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4784). | |||
| REF 2 | Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. | |||
| REF 3 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 4 | Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. Nat Biotechnol. 2003 May;21(5):566-9. | |||
| REF 5 | Melatonin protects against delta-aminolevulinic acid-induced oxidative damage in male Syrian hamster Harderian glands. Int J Biochem Cell Biol. 2002 May;34(5):544-53. | |||
| REF 6 | A novel mutation of delta-aminolaevulinate dehydratase in a healthy child with 12% erythrocyte enzyme activity. Br J Haematol. 1999 Sep;106(4):931-7. | |||
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