Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0Y7HC
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| Former ID |
DIB019340
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| Drug Name |
PMID12127536C20
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| Synonyms |
GTPL8650; BDBM50116264
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C34H38N6O8
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| Canonical SMILES |
CCC(C)C(C(=O)NC1CCC2=C3C(=CC=C2)CC(N3C1=O)C(=O)NC(CC(=O)O)C(=O)C4=NN=C(O4)C5=CC=CC=C5)N(C)C(=O)C
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| InChI |
1S/C34H38N6O8/c1-5-18(2)27(39(4)19(3)41)31(46)35-23-15-14-20-12-9-13-22-16-25(40(28(20)22)34(23)47)30(45)36-24(17-26(42)43)29(44)33-38-37-32(48-33)21-10-7-6-8-11-21/h6-13,18,23-25,27H,5,14-17H2,1-4H3,(H,35,46)(H,36,45)(H,42,43)/t18-,23-,24-,25-,27-/m0/s1
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| InChIKey |
UCXMBOHIKJZNMQ-GIYJSHOWSA-N
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Granzyme B (GZMB) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Natural killer cell mediated cytotoxicity | |||
| Type I diabetes mellitus | ||||
| Transcriptional misregulation in cancer | ||||
| Autoimmune thyroid disease | ||||
| Allograft rejection | ||||
| Graft-versus-host disease | ||||
| NetPath Pathway | IL9 Signaling Pathway | |||
| TCR Signaling Pathway | ||||
| IL2 Signaling Pathway | ||||
| IL4 Signaling Pathway | ||||
| Panther Pathway | Apoptosis signaling pathway | |||
| Pathway Interaction Database | IL12-mediated signaling events | |||
| Caspase Cascade in Apoptosis | ||||
| Downstream signaling in naï | ||||
| Reactome | NOTCH2 intracellular domain regulates transcription | |||
| WikiPathways | Oxidative phosphorylation | |||
| Signaling by NOTCH2 | ||||
| Apoptosis | ||||
| Allograft Rejection | ||||
| Intrinsic Pathway for Apoptosis | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Discovery of potent, selective human granzyme B inhibitors that inhibit CTL mediated apoptosis. Bioorg Med Chem Lett. 2002 Aug 19;12(16):2197-200. | |||
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