Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0Y6ST
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| Former ID |
DIB020890
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| Drug Name |
SAG
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| Synonyms |
1-stearoyl-2-arachidonoyl-sn-glycerol
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C28H28ClN3OS
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| Canonical SMILES |
CNC1CCC(CC1)N(CC2=CC(=CC=C2)C3=CC=NC=C3)C(=O)C4=C(C5=CC=CC=C5S4)Cl
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| InChI |
1S/C28H28ClN3OS/c1-30-22-9-11-23(12-10-22)32(28(33)27-26(29)24-7-2-3-8-25(24)34-27)18-19-5-4-6-21(17-19)20-13-15-31-16-14-20/h2-8,13-17,22-23,30H,9-12,18H2,1H3
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| InChIKey |
VFSUUTYAEQOIMW-UHFFFAOYSA-N
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| CAS Number |
CAS 364590-63-6
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| ChEBI ID |
CHEBI:138438
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Short transient receptor potential channel 2 (TRPC2) | Target Info | Activator | [2] |
| Short transient receptor potential channel 6 (TRPC6) | Target Info | Activator | [3] | |
| Panther Pathway | Alzheimer disease-presenilin pathway | |||
| Pathway Interaction Database | Endothelins | |||
| Nephrin/Neph1 signaling in the kidney podocyte | ||||
| EPO signaling pathway | ||||
| PAR1-mediated thrombin signaling events | ||||
| Reactome | Effects of PIP2 hydrolysis | |||
| TRP channels | ||||
| Role of second messengers in netrin-1 signaling | ||||
| WikiPathways | Primary Focal Segmental Glomerulosclerosis FSGS | |||
| Platelet homeostasis | ||||
| Netrin-1 signaling | ||||
| GPCR downstream signaling | ||||
| Effects of PIP2 hydrolysis | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2437). | |||
| REF 2 | A diacylglycerol-gated cation channel in vomeronasal neuron dendrites is impaired in TRPC2 mutant mice: mechanism of pheromone transduction. Neuron. 2003 Oct 30;40(3):551-61. | |||
| REF 3 | Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol. Nature. 1999 Jan 21;397(6716):259-63. | |||
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