Drug Information
Drug General Information | Top | |||
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Drug ID |
D0Y6HV
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Former ID |
DIB005317
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Drug Name |
EMD-53998
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Synonyms |
5-[1-(3,4-Dimethoxybenzoyl)-1,2,3,4-tetrahydroquinolin-6-yl]-6-methyl-3,6-dihydro-2H-1,3,4-thiadiazin-2-one
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Drug Type |
Small molecular drug
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Indication | Cardiovascular disease [ICD-11: BA00-BE2Z; ICD-10: I00-I99] | Discontinued in Phase 1 | [1] | |
Structure |
Download2D MOL |
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Formula |
C22H23N3O4S
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Canonical SMILES |
CC1C(=NNC(=O)S1)C2=CC3=C(C=C2)N(CCC3)C(=O)C4=CC(=C(C=C4)OC)OC
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InChI |
1S/C22H23N3O4S/c1-13-20(23-24-22(27)30-13)15-6-8-17-14(11-15)5-4-10-25(17)21(26)16-7-9-18(28-2)19(12-16)29-3/h6-9,11-13H,4-5,10H2,1-3H3,(H,24,27)
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InChIKey |
IZLRMTJLQCLMKF-UHFFFAOYSA-N
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CAS Number |
CAS 120223-04-3
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Phosphodiesterase 3A (PDE3A) | Target Info | Inhibitor | [2] |
KEGG Pathway | Purine metabolism | |||
cGMP-PKG signaling pathway | ||||
cAMP signaling pathway | ||||
Morphine addiction | ||||
Reactome | cGMP effects | |||
G alpha (s) signalling events | ||||
WikiPathways | miR-targeted genes in muscle cell - TarBase | |||
miR-targeted genes in lymphocytes - TarBase |
References | Top | |||
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REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000367) | |||
REF 2 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 |
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