Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0Y4ZS
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| Former ID |
DIB007410
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| Drug Name |
Endovion
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| Synonyms |
Angiogenesis inhibitor, NeuroSearch; Chloride channel antagonist, NeuroSearch; NS-1652; NS-3728
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| Drug Type |
Small molecular drug
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| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C76-C80; ICD-9: 140-229] | Terminated | [1], [2] | |
| Company |
NeuroSearch A/S
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| Structure |
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Download2D MOL |
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| Formula |
C16H9BrF6N6O
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| Canonical SMILES |
C1=CC(=C(C=C1Br)C2=NNN=N2)NC(=O)NC3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F
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| InChI |
1S/C16H9BrF6N6O/c17-9-1-2-12(11(6-9)13-26-28-29-27-13)25-14(30)24-10-4-7(15(18,19)20)3-8(5-10)16(21,22)23/h1-6H,(H2,24,25,30)(H,26,27,28,29)
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| InChIKey |
AEFYFGMSRKDXHZ-UHFFFAOYSA-N
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| CAS Number |
CAS 265646-85-3
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Chloride channel unspecific (ClC) | Target Info | Antagonist | [3] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4273). | |||
| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800013896) | |||
| REF 3 | Inhibition of the endogenous volume-regulated anion channel (VRAC) in HEK293 cells by acidic di-aryl-ureas. J Membr Biol. 2003 Nov 15;196(2):83-94. | |||
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