Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0XT5Y
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| Former ID |
DAP001053
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| Drug Name |
Sargramostim
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| Synonyms |
Leukine; Leukine (TN); Sargramostim (genetical recombination); Sargramostim (USAN/INN); Sargramostim (genetical recombination) (JAN)
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| Indication | Bone marrow transplantation [ICD-11: QB63.6; ICD-9: 279.5, 996] | Approved | [1], [2] | |
| Therapeutic Class |
Immunomodulatory Agents
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| Company |
Bayer Pharmaceuticals Corporation
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| PubChem Substance ID | ||||
| ADReCS Drug ID | BADD_D01990 | |||
| SuperDrug ATC ID |
L03AA09
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | GMCSFR-alpha (CSF2RA) | Target Info | Binder | [3], [4] |
| KEGG Pathway | Cytokine-cytokine receptor interaction | |||
| Jak-STAT signaling pathway | ||||
| Hematopoietic cell lineage | ||||
| Pathways in cancer | ||||
| NetPath Pathway | IL3 Signaling Pathway | |||
| RANKL Signaling Pathway | ||||
| Pathway Interaction Database | GMCSF-mediated signaling events | |||
| Alpha9 beta1 integrin signaling events | ||||
| Reactome | GPVI-mediated activation cascade | |||
| G beta:gamma signalling through PI3Kgamma | ||||
| Interleukin-3, 5 and GM-CSF signaling | ||||
| RAF/MAP kinase cascade | ||||
| Surfactant metabolism | ||||
| Interleukin receptor SHC signaling | ||||
| WikiPathways | Interleukin-2 signaling | |||
| Interleukin-3, 5 and GM-CSF signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7905). | |||
| REF 2 | Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. | |||
| REF 3 | Stem cell transplantation and hematopoietic growth factors. Curr Hematol Rep. 2002 Nov;1(2):103-9. | |||
| REF 4 | Economic evaluation of filgrastim, sargramostim, and sequential sargramostim and filgrastim after myelosuppressive chemotherapy. Bone Marrow Transplant. 2002 Jan;29(2):159-64. | |||
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