Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0X9ZC
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| Former ID |
DAP000446
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| Drug Name |
Cefadroxil
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| Synonyms |
CDX; Cefadroxilo; Cefadroxilum; Cephadroxil; Sumacef; Cefadroxil anhydrous; S 578; BL-S 578; BL-S578; Cefadroxil (JP15); Cefadroxilo [INN-Spanish]; Cefadroxilum [INN-Latin]; Curisafe (TN); D-Cefadroxil; S-578; Sumacef (TN); MJF-11567-3; (6R,7R)-7-((R)-2-Amino-2-(p-hydroxyphenyl)acetamido)-3-methyl-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid; (6R,7R)-7-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; (6R,7R)-7-{[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino}-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; 7beta-{[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino}-3,4-didehydrocepham-4-carboxylic acid
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| Drug Type |
Small molecular drug
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| Indication | Bacterial infection [ICD-11: 1A00-1C4Z; ICD-10: A00-B99] | Approved | [1], [2] | |
| Therapeutic Class |
Antibiotics
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| Company |
Pharco B international
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| Structure |
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Download2D MOL |
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| Formula |
C16H17N3O5S
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| Canonical SMILES |
CC1=C(N2C(C(C2=O)NC(=O)C(C3=CC=C(C=C3)O)N)SC1)C(=O)O
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| InChI |
1S/C16H17N3O5S/c1-7-6-25-15-11(14(22)19(15)12(7)16(23)24)18-13(21)10(17)8-2-4-9(20)5-3-8/h2-5,10-11,15,20H,6,17H2,1H3,(H,18,21)(H,23,24)/t10-,11-,15-/m1/s1
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| InChIKey |
BOEGTKLJZSQCCD-UEKVPHQBSA-N
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| CAS Number |
CAS 50370-12-2
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9095, 7847323, 7978892, 8149235, 10990583, 11335584, 11360823, 11362958, 11365520, 11368082, 11373871, 11376244, 11461795, 11466462, 11467582, 11483750, 11486123, 11487903, 11492081, 11493918, 14852631, 16050996, 24892921, 25622160, 34712894, 46509128, 47440185, 47515253, 47515254, 47959665, 48035040, 48334422, 48415709, 49699087, 50124273, 57654040, 75439952, 85279381, 87322627, 90451718, 92125414, 93576133, 93576712, 99301497, 103620148, 103914339, 104133801, 104354273, 121363085, 124766005
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| ChEBI ID |
CHEBI:3479
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| ADReCS Drug ID | BADD_D00379 ; BADD_D00380 ; BADD_D00381 | |||
| SuperDrug ATC ID |
J01DB05
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| SuperDrug CAS ID |
cas=050370122
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Abundace of Studied Microbe(s) Regulated by Drug | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
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Studied Microbe: Blautia obeum
Show/Hide Hierarchy
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Blautia obeum was decreased by Cefadroxil (adjusted p-values: 7.23E-04). | |||
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Studied Microbe: Roseburia hominis
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Roseburia hominis was decreased by Cefadroxil (adjusted p-values: 2.68E-03). | |||
| Target and Pathway | Top | |||
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| Target(s) | Bacterial Penicillin binding protein (Bact PBP) | Target Info | Binder | [4] |
| References | Top | |||
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| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4831). | |||
| REF 2 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 062291. | |||
| REF 3 | Extensive impact of non-antibiotic drugs on human gut bacteria. Nature. 2018 Mar 29;555(7698):623-628. | |||
| REF 4 | Penicillin-binding protein sensitive to cephalexin in sporulation of Bacillus cereus. Microbiol Res. 1997 Sep;152(3):227-32. | |||
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