Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0X9XP
|
|||
| Former ID |
DIB015075
|
|||
| Drug Name |
Diosmin
|
|||
| Synonyms |
D3908
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Hemorrhoids [ICD-11: DB60; ICD-10: K64.8] | Approved | [1] | |
| Structure |
 |
Download2D MOL |
||
| Formula |
C28H32O15
|
|||
| Canonical SMILES |
CC1C(C(C(C(O1)OCC2C(C(C(C(O2)OC3=CC(=C4C(=C3)OC(=CC4=O)C5=CC(=C(C=C5)OC)O)O)O)O)O)O)O)O
|
|||
| InChI |
1S/C28H32O15/c1-10-21(32)23(34)25(36)27(40-10)39-9-19-22(33)24(35)26(37)28(43-19)41-12-6-14(30)20-15(31)8-17(42-18(20)7-12)11-3-4-16(38-2)13(29)5-11/h3-8,10,19,21-30,32-37H,9H2,1-2H3/t10-,19+,21-,22+,23+,24-,25+,26+,27+,28+/m0/s1
|
|||
| InChIKey |
GZSOSUNBTXMUFQ-YFAPSIMESA-N
|
|||
| CAS Number |
CAS 520-27-4
|
|||
| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:4631
|
|||
| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bifidobacteriales | ||||
|
Studied Microbe: Bifidobacterium
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Metabolic Reaction | Glycosidic bond generation | |||
| Resulting Metabolite | Diosmetin | |||
| Description | Diosmin can be metabolized to Diosmetin by Bifidobacterium through glycosidic bond generation. | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Enterobacterales | ||||
|
Studied Microbe: Escherichia
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Metabolic Reaction | Glycosidic bond generation | |||
| Resulting Metabolite | Diosmetin | |||
| Description | Diosmin can be metabolized to Diosmetin by Escherichia through glycosidic bond generation. | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
|
Studied Microbe: Clostridium
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Metabolic Reaction | Glycosidic bond generation | |||
| Resulting Metabolite | Diosmetin | |||
| Description | Diosmin can be metabolized to Diosmetin by Clostridium through glycosidic bond generation. | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Lactobacillales | ||||
|
Studied Microbe: Enterococcus
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Metabolic Reaction | Glycosidic bond generation | |||
| Resulting Metabolite | Diosmetin | |||
| Description | Diosmin can be metabolized to Diosmetin by Enterococcus through glycosidic bond generation. | |||
|
Studied Microbe: Lactobacillus
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Metabolic Reaction | Glycosidic bond generation | |||
| Resulting Metabolite | Diosmetin | |||
| Description | Diosmin can be metabolized to Diosmetin by Lactobacillus through glycosidic bond generation. | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 2 | Effects of Gut Microbiota on Drug Metabolism and Guidance for Rational Drug Use Under Hypoxic Conditions at High Altitudes. Curr Drug Metab. 2019;20(2):155-165. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.