Drug Information
Drug General Information | Top | |||
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Drug ID |
D0X9LK
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Former ID |
DIB014808
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Drug Name |
Iralukast
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Synonyms |
CGP-45715A
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Drug Type |
Small molecular drug
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Indication | Asthma [ICD-11: CA23; ICD-10: J45, J45.8; ICD-9: 493] | Phase 2 | [1], [2] | |
Company |
Novartis AG
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Structure |
Download2D MOL |
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Formula |
C38H37F3O8S
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Canonical SMILES |
CCCC1=C(C=CC(=C1O)C(=O)C)OCCCCC=CC=CC(C(C2=CC(=CC=C2)C(F)(F)F)O)SC3=CC4=C(C=C3)C(=O)C=C(O4)C(=O)O
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InChI |
1S/C38H37F3O8S/c1-3-11-29-31(18-17-27(23(2)42)36(29)45)48-19-9-7-5-4-6-8-14-34(35(44)24-12-10-13-25(20-24)38(39,40)41)50-26-15-16-28-30(43)22-33(37(46)47)49-32(28)21-26/h4,6,8,10,12-18,20-22,34-35,44-45H,3,5,7,9,11,19H2,1-2H3,(H,46,47)/b6-4-,14-8+/t34-,35+/m0/s1
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InChIKey |
IXJCHVMUTFCRBH-SDUHDBOFSA-N
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CAS Number |
CAS 151581-24-7
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PubChem Compound ID | ||||
PubChem Substance ID |
Target and Pathway | Top | |||
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Target(s) | Leukotriene CysLT1 receptor (CYSLTR1) | Target Info | Modulator | [3] |
KEGG Pathway | Calcium signaling pathway | |||
Neuroactive ligand-receptor interaction | ||||
NetPath Pathway | TGF_beta_Receptor Signaling Pathway | |||
IL4 Signaling Pathway | ||||
IL3 Signaling Pathway | ||||
Pathway Interaction Database | Endothelins | |||
Reactome | Leukotriene receptors | |||
G alpha (q) signalling events | ||||
WikiPathways | GPCRs, Class A Rhodopsin-like | |||
Gastrin-CREB signalling pathway via PKC and MAPK | ||||
GPCR ligand binding | ||||
GPCR downstream signaling |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5861). | |||
REF 2 | Iralukast Novartis AG. IDrugs. 1998 May;1(1):147-50. | |||
REF 3 | Pharmacological characterization of the cysteinyl-leukotriene antagonists CGP 45715A (iralukast) and CGP 57698 in human airways in vitro. Br J Pharmacol. 1998 Feb;123(3):590-8. |
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