Drug Information
Drug General Information | Top | |||
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Drug ID |
D0X8XA
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Former ID |
DIB008078
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Drug Name |
Sulconazole
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Synonyms |
Exelderm; Sulcosyn
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Drug Type |
Small molecular drug
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Indication | Fungal infection [ICD-11: 1F29-1F2F; ICD-10: B35-B49; ICD-9: 110-118] | Approved | [1] | |
Therapeutic Class |
Antiinfective Agents
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Company |
Ranbaxy Laboratories Inc
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Structure |
Download2D MOL |
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Formula |
C18H15Cl3N2S
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Canonical SMILES |
C1=CC(=CC=C1CSC(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl)Cl
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InChI |
1S/C18H15Cl3N2S/c19-14-3-1-13(2-4-14)11-24-18(10-23-8-7-22-12-23)16-6-5-15(20)9-17(16)21/h1-9,12,18H,10-11H2
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InChIKey |
AFNXATANNDIXLG-UHFFFAOYSA-N
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CAS Number |
CAS 61318-90-9
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PubChem Compound ID | ||||
ChEBI ID |
CHEBI:77776
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ADReCS Drug ID | BADD_D02086 ; BADD_D02087 |
Interaction between the Drug and Microbe | Top | |||
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The Abundace of Studied Microbe(s) Regulated by Drug | ||||
The Order in the Taxonomic Hierarchy of the following Microbe(s): Coriobacteriales | ||||
Studied Microbe: Collinsella aerofaciens
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Collinsella aerofaciens was decreased by Sulconazole nitrate (adjusted p-values: 2.74E-07). | |||
The Order in the Taxonomic Hierarchy of the following Microbe(s): Erysipelotrichales | ||||
Studied Microbe: Erysipelatoclostridium ramosum
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Erysipelatoclostridium ramosum was decreased by Sulconazole nitrate (adjusted p-values: 8.09E-04). | |||
The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
Studied Microbe: Blautia obeum
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Blautia obeum was decreased by Sulconazole nitrate (adjusted p-values: 7.48E-07). | |||
Studied Microbe: Clostridium perfringens
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Clostridium perfringens was decreased by Sulconazole nitrate (adjusted p-values: 3.08E-05). | |||
Studied Microbe: Coprococcus comes
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Coprococcus comes was decreased by Sulconazole nitrate (adjusted p-values: 5.04E-06). | |||
Studied Microbe: Dorea formicigenerans
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Dorea formicigenerans was decreased by Sulconazole nitrate (adjusted p-values: 5.04E-06). | |||
Studied Microbe: Enterocloster bolteae
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Enterocloster bolteae was decreased by Sulconazole nitrate (adjusted p-values: 5.75E-03). | |||
Studied Microbe: Eubacterium eligens
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Eubacterium eligens was decreased by Sulconazole nitrate (adjusted p-values: 6.82E-06). | |||
Studied Microbe: Eubacterium rectale
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Eubacterium rectale was decreased by Sulconazole nitrate (adjusted p-values: 1.63E-04). | |||
Studied Microbe: Roseburia hominis
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Roseburia hominis was decreased by Sulconazole nitrate (adjusted p-values: 2.39E-05). | |||
Studied Microbe: Roseburia intestinalis
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Roseburia intestinalis was decreased by Sulconazole nitrate (adjusted p-values: 2.47E-04). | |||
Studied Microbe: Ruminococcus bromii
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Ruminococcus bromii was decreased by Sulconazole nitrate (adjusted p-values: 1.78E-05). | |||
Studied Microbe: Ruminococcus gnavus
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Ruminococcus gnavus was decreased by Sulconazole nitrate (adjusted p-values: 5.04E-06). | |||
Studied Microbe: Ruminococcus torques
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Ruminococcus torques was decreased by Sulconazole nitrate (adjusted p-values: 1.95E-06). |
References | Top | |||
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REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
REF 2 | Extensive impact of non-antibiotic drugs on human gut bacteria. Nature. 2018 Mar 29;555(7698):623-628. |
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