Drug Information
Drug General Information | Top | |||
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Drug ID |
D0X7HM
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Former ID |
DAP000535
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Drug Name |
Carboplatin
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Synonyms |
Azanide; Carbopaltin; Carboplatine; Carboplatino; Carboplatinum; Cbdca; Ercar; Paraplatin; Carboplatine [French]; Carboplatino [Spanish]; Carboplatinum [Latin]; C 2538; JM 8; Carboplatin (USAN); IUPAC: Azane; JM-8; Paraplatin (TN); Paraplatin, Carboplatin; Paraplatin-AQ; Cis-Diammine(cyclobutanedicarboxylato)platinumII; Platinum(+2) Cation; Carboplatin (JAN/USP/INN); Carboplatin [USAN:INN:BAN:JAN]; Cyclobutane-1,1-dicarboxylate; Cyclobutane-1,1-dicarboxylic acid; Diammine-1,1-cyclobutane dicarboxylate platinum II; Cis-Diamine[1,1-cyclobutanedicarboxylato]platinum(II); Cis-Diammine(1,1-cyclobutanedicarboxylato) platinum; Cis-Diammine(1,1-cyclobutanedicarboxylato)platinum; Cis-Diammine[1,1-cyclobutane-dicarboxylato] platinum; Diammine(1,1-cyclobutanedicarboxylato)platinum (II); Platinum, {diammine[1,1-cyclobut; Cis-(1,1-Cyclobutanedicarboxylato)diammineplatinum(II); Cis-Diamine(1,1-cyclobutanedicarboxylato)platinum(II); Cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II); Platinum(II), (1, 1-cyclobutanedicar; Diammine[cyclobutane-1,1-dicarboxylato(2-)-k2O1,O1]platinum; Diammine(cyclobutane-1,1-dicarboxylato(2-)-O,O')platinum; Platinum, diammine(1,1-cyclobutanedicarboxylato(2-)-O,O')-, (SP-4-2); (SP-4-2)-diammine[cyclobutane-1,1-dicarboxylato(2-)-kappa(2)O,O']platinum; 1,1-Cyclobutanedicarboxylate diammine platinum (II); 1,1-Cyclobutanedicarboxylate diammine platinum(II)
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Drug Type |
Small molecular drug
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Indication | Ovarian cancer [ICD-11: 2C73; ICD-10: C56; ICD-9: 183] | Approved | [1], [2] | |
Therapeutic Class |
Anticancer Agents
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Company |
Bristol-Myers Squibb
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Structure |
Download2D MOL
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Formula |
C6H12N2O4Pt
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Canonical SMILES |
C1CC(C1)(C(=O)O)C(=O)O.[NH2-].[NH2-].[Pt+2]
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InChI |
1S/C6H8O4.2H2N.Pt/c7-4(8)6(5(9)10)2-1-3-6;;;/h1-3H2,(H,7,8)(H,9,10);2*1H2;/q;2*-1;+2
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InChIKey |
VSRXQHXAPYXROS-UHFFFAOYSA-N
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CAS Number |
CAS 41575-94-4
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PubChem Compound ID | ||||
PubChem Substance ID |
15350457, 22704376, 33972238, 75354552, 87558792, 117682520, 127293893, 127293894, 127293895, 127293896, 127293897, 127293898, 127293899, 127293900, 127293901, 127293902, 127293903, 127293904, 127293905, 127293906, 127293907, 127293908, 127293909, 127293910, 127293911, 127293912, 127293913, 127293914, 127293915, 127293916, 127293917, 127293918, 127293919, 127293920, 127293921, 127293922, 127293923, 127293924, 127293925, 127293926, 127293927, 127293928, 127293929, 127293930, 127293931, 127293932, 127293933, 127293934, 127293935, 127293936
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ChEBI ID |
CHEBI:31355
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ADReCS Drug ID | BADD_D00364 | |||
SuperDrug ATC ID |
L01XA02
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SuperDrug CAS ID |
cas=041575944
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Interaction between the Drug and Microbe | Top | |||
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The Metabolism of Drug Affected by Studied Microbe(s) | ||||
The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
Studied Microbe: Prevotella copri
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[3] | |||
Hierarchy | ||||
Metabolic Effect | Increase side effect (intestinal mucositis) | |||
Description | Carboplatin can be metabolized by Prevotella copri, which results in the increase of the drug's side effect (intestinal mucositis). |
Target and Pathway | Top | |||
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Target(s) | Human Deoxyribonucleic acid (hDNA) | Target Info | Modulator | [4] |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7624). | |||
REF 2 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 076039. | |||
REF 3 | Toxicomicrobiomics: The Human Microbiome vs. Pharmaceutical, Dietary, and Environmental Xenobiotics. Front Pharmacol. 2020 Apr 16;11:390. | |||
REF 4 | Inhibition of carboplatin-induced DNA interstrand cross-link repair by gemcitabine in patients receiving these drugs for platinum-resistant ovarian cancer.Clin Cancer Res.2010 Oct 1;16(19):4899-905. |
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