Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0X6BV
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| Former ID |
DCL001036
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| Drug Name |
Vilazodone
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| Synonyms |
Vilazodone [INN]; Vilazodone (TN); 5-[4-[4-(5-cyano-1H-indol-3-yl)butyl]piperazin-1-yl]-1-benzofuran-2-carboxamide; 5-[4-[4-(5-cyano-1H-indol-3-yl)butyl]piperazin-1-yl]benzofuran-2-carboxamide
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| Drug Type |
Small molecular drug
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| Indication | Major depressive disorder [ICD-11: 6A70.3; ICD-10: F32.2] | Approved | [1], [2] | |
| Company |
Genaissance and Merck KGaA
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| Structure |
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Download2D MOL |
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| Formula |
C26H27N5O2
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| Canonical SMILES |
C1CN(CCN1CCCCC2=CNC3=C2C=C(C=C3)C#N)C4=CC5=C(C=C4)OC(=C5)C(=O)N
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| InChI |
1S/C26H27N5O2/c27-16-18-4-6-23-22(13-18)19(17-29-23)3-1-2-8-30-9-11-31(12-10-30)21-5-7-24-20(14-21)15-25(33-24)26(28)32/h4-7,13-15,17,29H,1-3,8-12H2,(H2,28,32)
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| InChIKey |
SGEGOXDYSFKCPT-UHFFFAOYSA-N
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| CAS Number |
CAS 163521-12-8
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| PubChem Compound ID | ||||
| PubChem Substance ID |
14930538, 23950818, 43529694, 76910791, 85210119, 93300539, 103455044, 104040116, 114787770, 124490438, 126681745, 129231444, 134339460, 135270095, 137083322, 137188808, 141233041, 152064163, 152258562, 160645967, 160647397, 160831434, 162011476, 162224429, 163094960, 163392752, 164045358, 164766116, 170501384, 172914663, 175268384, 175427083, 178103999, 186005325, 198993119, 204388973, 223393050, 223536020, 223660986, 224093528, 226949401, 242060090, 246074631, 249863492, 251875390, 251916863, 251918102, 251971270, 252067762, 252091522
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| ChEBI ID |
CHEBI:70707
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| ADReCS Drug ID | BADD_D02356 ; BADD_D02456 | |||
| SuperDrug ATC ID |
N06AX24
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
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Studied Microbe: Alistipes indistinctus DSM22520
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Vilazodone can be metabolized by Alistipes indistinctus DSM22520 (log2FC = -0.377; p = 0.003). | |||
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Studied Microbe: Bacteroides cellulosilyticus DSM 14838
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Vilazodone can be metabolized by Bacteroides cellulosilyticus DSM 14838 (log2FC = -4.23; p = 0.003). | |||
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Studied Microbe: Bacteroides coprophilus DSM 18228
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Vilazodone can be metabolized by Bacteroides coprophilus DSM 18228 (log2FC = -6.018; p = 0.001). | |||
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Studied Microbe: Bacteroides dorei DSM 17855
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Vilazodone can be metabolized by Bacteroides dorei DSM 17855 (log2FC = -8.699; p = 0.003). | |||
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Studied Microbe: Bacteroides eggerthii DSM20697
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Vilazodone can be metabolized by Bacteroides eggerthii DSM20697 (log2FC = -4.737; p = 0.007). | |||
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Studied Microbe: Bacteroides fragilis ATCC43859
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Vilazodone can be metabolized by Bacteroides fragilis ATCC43859 (log2FC = -11.194; p = 0.001). | |||
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Studied Microbe: Bacteroides fragilis HMW 610
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Vilazodone can be metabolized by Bacteroides fragilis HMW 610 (log2FC = -7.198; p = 0.001). | |||
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Studied Microbe: Bacteroides fragilis HMW 615
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Vilazodone can be metabolized by Bacteroides fragilis HMW 615 (log2FC = -3.726; p = 0.004). | |||
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Studied Microbe: Bacteroides fragilis NCTC 9343
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Vilazodone can be metabolized by Bacteroides fragilis NCTC 9343 (log2FC = -7.304; p = 0.002). | |||
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Studied Microbe: Bacteroides fragilis str. 3397 T10
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Vilazodone can be metabolized by Bacteroides fragilis str. 3397 T10 (log2FC = -9.985; p = 0.002). | |||
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Studied Microbe: Bacteroides fragilis str. 3986 T(B)9
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Vilazodone can be metabolized by Bacteroides fragilis str. 3986 T(B)9 (log2FC = -5.379; p = 0.003). | |||
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Studied Microbe: Bacteroides fragilis str. DS-208
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Vilazodone can be metabolized by Bacteroides fragilis str. DS-208 (log2FC = -8.232; p = 0.003). | |||
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Studied Microbe: Bacteroides intestinalis DSM 17393
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Vilazodone can be metabolized by Bacteroides intestinalis DSM 17393 (log2FC = -6.287; p = 0.0). | |||
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Studied Microbe: Bacteroides ovatus ATCC 8483
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Vilazodone can be metabolized by Bacteroides ovatus ATCC 8483 (log2FC = -3.049; p = 0.01). | |||
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Studied Microbe: Bacteroides stercoris ATCC 43183
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Vilazodone can be metabolized by Bacteroides stercoris ATCC 43183 (log2FC = -9.163; p = 0.002). | |||
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Studied Microbe: Bacteroides thetaiotaomicron 3731
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Vilazodone can be metabolized by Bacteroides thetaiotaomicron 3731 (log2FC = -0.772; p = 0.001). | |||
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Studied Microbe: Bacteroides thetaiotaomicron 7330
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Vilazodone can be metabolized by Bacteroides thetaiotaomicron 7330 (log2FC = -1.525; p = 0.0). | |||
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Studied Microbe: Bacteroides thetaiotaomicron VPI-5482
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Vilazodone can be metabolized by Bacteroides thetaiotaomicron VPI-5482 (log2FC = -1.714; p = 0.0). | |||
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Studied Microbe: Bacteroides uniformis ATCC 8492
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Vilazodone can be metabolized by Bacteroides uniformis ATCC 8492 (log2FC = -5.075; p = 0.001). | |||
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Studied Microbe: Bacteroides vulgatus ATCC 8482
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Vilazodone can be metabolized by Bacteroides vulgatus ATCC 8482 (log2FC = -9.9; p = 0.004). | |||
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Studied Microbe: Bacteroides WH2
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Vilazodone can be metabolized by Bacteroides WH2 (log2FC = -6.449; p = 0.002). | |||
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Studied Microbe: Bacteroides xylanisolvens DSM18836
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Vilazodone can be metabolized by Bacteroides xylanisolvens DSM18836 (log2FC = -3.4; p = 0.0). | |||
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Studied Microbe: Odoribacter splanchnicus
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Vilazodone can be metabolized by Odoribacter splanchnicus (log2FC = -8.091; p = 0.002). | |||
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Studied Microbe: Parabacteroides distasonis ATCC 8503
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Vilazodone can be metabolized by Parabacteroides distasonis ATCC 8503 (log2FC = -7.602; p = 0.001). | |||
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Studied Microbe: Parabacteroides johnsonii DSM 18315
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Vilazodone can be metabolized by Parabacteroides johnsonii DSM 18315 (log2FC = -6.742; p = 0.001). | |||
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Studied Microbe: Parabacteroides merdae ATCC 43184
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Vilazodone can be metabolized by Parabacteroides merdae ATCC 43184 (log2FC = -5.485; p = 0.002). | |||
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Studied Microbe: Pretovella copri DSM 18205
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Vilazodone can be metabolized by Pretovella copri DSM 18205 (log2FC = -0.634; p = 0.002). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Erysipelotrichales | ||||
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Studied Microbe: Clostridium spiroforme DSM1552
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Vilazodone can be metabolized by Clostridium spiroforme DSM1552 (log2FC = -1.675; p = 0.007). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
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Studied Microbe: Clostridium sporogenes ATCC 15579
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Vilazodone can be metabolized by Clostridium sporogenes ATCC 15579 (log2FC = -1.025; p = 0.003). | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | 5-HT 1A receptor (HTR1A) | Target Info | Modulator | [2] |
| Serotonin transporter (SERT) | Target Info | Modulator | [2] | |
| KEGG Pathway | Serotonergic synapse | |||
| cAMP signaling pathway | ||||
| Neuroactive ligand-receptor interaction | ||||
| NetPath Pathway | TCR Signaling Pathway | |||
| Panther Pathway | 5HT1 type receptor mediated signaling pathway | |||
| 5HT2 type receptor mediated signaling pathway | ||||
| 5HT3 type receptor mediated signaling pathway | ||||
| 5HT4 type receptor mediated signaling pathway | ||||
| Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| Reactome | Serotonin receptors | |||
| G alpha (i) signalling events | ||||
| WikiPathways | Monoamine Transport | |||
| SIDS Susceptibility Pathways | ||||
| NRF2 pathway | ||||
| Synaptic Vesicle Pathway | ||||
| Serotonin Transporter Activity | ||||
| Serotonin HTR1 Group and FOS Pathway | ||||
| Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7427). | |||
| REF 2 | 2011 FDA drug approvals. Nat Rev Drug Discov. 2012 Feb 1;11(2):91-4. | |||
| REF 3 | Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467. | |||
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