Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0X5OV
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| Former ID |
DIB008203
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| Drug Name |
TTA-A8
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| Synonyms |
TTA-A2; TTA-P2; T-type calcium channel antagonists, Merck & Co
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| Drug Type |
Small molecular drug
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| Indication | Insomnia [ICD-11: 7A00-7A0Z] | Preclinical | [1], [2] | |
| Company |
Merck & Co Inc
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| Structure |
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Download2D MOL |
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| Formula |
C22H21F3N4O2
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| Canonical SMILES |
CC1=NC=CN=C1C2=CC=C(C=C2)CC(=O)NC(C)C3=NC=C(C=C3)OCC(F)(F)F
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| InChI |
1S/C22H21F3N4O2/c1-14(19-8-7-18(12-28-19)31-13-22(23,24)25)29-20(30)11-16-3-5-17(6-4-16)21-15(2)26-9-10-27-21/h3-10,12,14H,11,13H2,1-2H3,(H,29,30)/t14-/m1/s1
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| InChIKey |
OURCOVUGQRXRTE-CQSZACIVSA-N
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Voltage-gated calcium channel alpha Cav3.2 (CACNA1H) | Target Info | Antagonist | [3] |
| KEGG Pathway | MAPK signaling pathway | |||
| Calcium signaling pathway | ||||
| Circadian entrainment | ||||
| Pathwhiz Pathway | Muscle/Heart Contraction | |||
| Reactome | NCAM1 interactions | |||
| WikiPathways | Corticotropin-releasing hormone | |||
| NCAM signaling for neurite out-growth | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7724). | |||
| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010094) | |||
| REF 3 | Short-acting T-type calcium channel antagonists significantly modify sleep architecture in rodents. ACS Med Chem Lett. 2010 Aug 24;1(9):504-9. | |||
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