Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0X4ZR
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| Former ID |
DAP000052
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| Drug Name |
Bupropion
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| Synonyms |
bupropion; Amfebutamone; 34911-55-2; Amfebutamon; 2-(tert-butylamino)-1-(3-chlorophenyl)propan-1-one; amfebutamonum; Amfebutamona; (+-)-Bupropion; Wellbatrin; Bupropion [INN:BAN]; 34841-39-9; Elontril; Amfebutamonum [INN-Latin]; Zyban; Amfebutamona [INN-Spanish]; Bupropion SR; AMFEBUTAMONE HCl; alpha-(tert-butylamino)-m-chloropropiophenone; CHEMBL894; BRN 2101062; (+-)-1-(3-chlorophenyl)-2-((1,1-dimethylethyl)amino)-1-propanone; CHEBI:3219; SNPPWIUOZRMYNY-UHFFFAOYSA-N; 1-(3-chlorophenyl)-2-[(1,1-dimethylethyl)amino]propan-1-one; Amfebutamon; Amfebutamonum; Elont; Bupropion Hcl; Bupropion hydrocloride; Bupropion (INN); Bupropion (Old RN); Bupropion (USAN); Alpha-(tert-Butylamino)-m-chloropropiophenone; Alpha-(tert-butylamino)-m-chloropropiophenone; (-)-2-(tert-Butylamino)-3'-chloropropiophenone; (-)-2-(tert-Butylamino)-3'-chlorpropiophenon; 1-Propanone; 2-(Tert-Butylamino)-3'-chloropropiophenone
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| Drug Type |
Small molecular drug
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| Indication | Smoking dependence [ICD-11: 6C4A.2; ICD-10: F17.2; ICD-9: 292] | Approved | [1] | |
| Company |
GlaxoSmithKline plc
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| Structure |
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Download2D MOL |
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| Formula |
C13H18ClNO
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| Canonical SMILES |
CC(C(=O)C1=CC(=CC=C1)Cl)NC(C)(C)C
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| InChI |
1S/C13H18ClNO/c1-9(15-13(2,3)4)12(16)10-6-5-7-11(14)8-10/h5-9,15H,1-4H3
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| InChIKey |
SNPPWIUOZRMYNY-UHFFFAOYSA-N
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| CAS Number |
CAS 34911-55-2
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9078, 794792, 4652643, 8150639, 11342225, 11362408, 11364557, 11367119, 11369681, 11371567, 11374307, 11377843, 11407107, 11466277, 11467397, 11485553, 11485993, 11487810, 11489475, 11490460, 11492429, 11495477, 15196401, 17425136, 24438813, 46386681, 46506896, 47217436, 47440956, 47515983, 47515984, 47589662, 47960423, 48335208, 48415666, 49681731, 49698964, 49832545, 50023786, 50105235, 51091903, 53786854, 56313588, 57320212, 79472453, 85209446, 85788458, 90340803, 92308360, 92308810
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| ChEBI ID |
CHEBI:3219
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| ADReCS Drug ID | BADD_D00312 ; BADD_D00313 ; BADD_D00314 | |||
| SuperDrug ATC ID |
N06AX12
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| SuperDrug CAS ID |
cas=034911552
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bifidobacteriales | ||||
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Studied Microbe: Bifidobacterium ruminantium
Show/Hide Hierarchy
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Bupropion can be metabolized by Bifidobacterium ruminantium (log2FC = -0.682; p = 0.035). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Enterobacterales | ||||
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Studied Microbe: Escherichia coli BW25113
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Bupropion can be metabolized by Escherichia coli BW25113 (log2FC = -0.598; p = 0.011). | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Norepinephrine transporter (NET) | Target Info | Inhibitor | [3] |
| Serotonin transporter (SERT) | Target Info | Inhibitor | [3] | |
| KEGG Pathway | Serotonergic synapse | |||
| NetPath Pathway | TCR Signaling Pathway | |||
| Panther Pathway | 5HT1 type receptor mediated signaling pathway | |||
| 5HT2 type receptor mediated signaling pathway | ||||
| 5HT3 type receptor mediated signaling pathway | ||||
| 5HT4 type receptor mediated signaling pathway | ||||
| Adrenaline and noradrenaline biosynthesis | ||||
| Reactome | Na+/Cl- dependent neurotransmitter transporters | |||
| WikiPathways | Monoamine Transport | |||
| SIDS Susceptibility Pathways | ||||
| NRF2 pathway | ||||
| Synaptic Vesicle Pathway | ||||
| Serotonin Transporter Activity | ||||
| Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 2 | Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467. | |||
| REF 3 | Clinically relevant drug interactions with new generation antidepressants and antipsychotics. Ther Umsch. 2009 Jun;66(6):485-92. | |||
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