Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0X3MK
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| Former ID |
DIB019794
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| Drug Name |
DZNep
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| Synonyms |
3-deazaneplanocin A
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C12H14N4O3
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| Canonical SMILES |
C1=CN=C(C2=C1N(C=N2)C3C=C(C(C3O)O)CO)N
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| InChI |
1S/C12H14N4O3/c13-12-9-7(1-2-14-12)16(5-15-9)8-3-6(4-17)10(18)11(8)19/h1-3,5,8,10-11,17-19H,4H2,(H2,13,14)/t8-,10-,11+/m1/s1
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| InChIKey |
OMKHWTRUYNAGFG-IEBDPFPHSA-N
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| CAS Number |
CAS 102052-95-9
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| PubChem Compound ID | ||||
| PubChem Substance ID |
615106, 8195549, 15221583, 24717549, 43129111, 75061254, 92098549, 103064415, 103078364, 103405348, 104354458, 109693483, 117524162, 118047210, 126683146, 135030528, 137263204, 138769807, 152258216, 152344544, 160647052, 162768946, 184607915, 186014818, 204400609, 223653078, 227133899, 237369420, 249492591, 252214387, 252392863, 252428751, 252476359
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Adenosylhomocysteinase (AHCY) | Target Info | Inhibitor | [1] |
| BioCyc | Superpathway of methionine degradation | |||
| Methionine degradation | ||||
| Cysteine biosynthesis | ||||
| KEGG Pathway | Cysteine and methionine metabolism | |||
| Metabolic pathways | ||||
| Pathwhiz Pathway | Selenoamino Acid Metabolism | |||
| Betaine Metabolism | ||||
| Methionine Metabolism | ||||
| WikiPathways | Metabolism of amino acids and derivatives | |||
| Trans-sulfuration and one carbon metabolism | ||||
| One Carbon Metabolism | ||||
| Trans-sulfuration pathway | ||||
| Phase II conjugation | ||||
| Folate Metabolism | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | 3-Deazaneplanocin: a new and potent inhibitor of S-adenosylhomocysteine hydrolase and its effects on human promyelocytic leukemia cell line HL-60. Biochem Biophys Res Commun. 1986 Mar 13;135(2):688-94. | |||
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