Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0X1EX
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| Former ID |
DIB006964
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| Drug Name |
TIBENELAST
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| Synonyms |
LY-186655 (sodium salt); Tibenelast; 5,6-Diethoxybenzothiophene-2-carboxylic acid
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| Drug Type |
Small molecular drug
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| Indication | Asthma [ICD-11: CA23; ICD-10: J45, J45.8; ICD-9: 493] | Discontinued in Phase 2 | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C13H14O4S
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| Canonical SMILES |
CCOC1=C(C=C2C(=C1)C=C(S2)C(=O)O)OCC
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| InChI |
1S/C13H14O4S/c1-3-16-9-5-8-6-12(13(14)15)18-11(8)7-10(9)17-4-2/h5-7H,3-4H2,1-2H3,(H,14,15)
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| InChIKey |
PDUXMHXBBXXJFQ-UHFFFAOYSA-N
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| CAS Number |
CAS 97852-72-7
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Phosphodiesterase (PDE) | Target Info | Inhibitor | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000078) | |||
| REF 2 | Effect of tibenelast (a phosphodiesterase inhibitor) and theophylline on isoproterenol-stimulated heart rate, cyclic AMP and norepinephrine levels. Pharmacology. 1993;46(3):142-7. | |||
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