Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0X0UR
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| Former ID |
DIB020235
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| Drug Name |
LPA
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| Synonyms |
2-Hydroxy-3-(phosphonooxy)propyl oleate; lysophosphatidic acid; 1-Oleoyl-lyso-phosphatidic acid; Monooleylphosphatidic acid; Oleoyl lysophosphatidic acid; 1-Oleyllysophosphatidic acid; 22002-87-5; (2-hydroxy-3-phosphonooxypropyl) (Z)-octadec-9-enoate; 1-oleoyl-LPA; monooleylphosphatidate; [3H]1-oleoyl-LPA; [3H]lysophosphatidic acid; [3H]LPA; 1-oleoyl-lysophosphatidic acid; [3H]-LPA; AC1NUZKL; Lysophosphophatidic acid; Oleoyl lysophosphatidate; 1-Oleyllysophosphatidate; 1-Oleoyl-lysophosphatidate; lysophosphatidic acid
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1], [2] | |
| Structure |
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Download2D MOL
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| Formula |
C21H41O7P
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| Canonical SMILES |
CCCCCCCCC=CCCCCCCCC(=O)OCC(COP(=O)(O)O)O
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| InChI |
1S/C21H41O7P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(23)27-18-20(22)19-28-29(24,25)26/h9-10,20,22H,2-8,11-19H2,1H3,(H2,24,25,26)/b10-9-
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| InChIKey |
WRGQSWVCFNIUNZ-KTKRTIGZSA-N
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| CAS Number |
CAS 22002-87-5
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5395). | |||
| REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2906). | |||
| REF 3 | Identification of the orphan GPCR, P2Y(10) receptor as the sphingosine-1-phosphate and lysophosphatidic acid receptor. Biochem Biophys Res Commun. 2008 Jul 11;371(4):707-12. | |||
| REF 4 | Molecular cloning and characterization of a novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid. J Biol Chem. 1999 Sep 24;274(39):27776-85. | |||
| REF 5 | Diversity of lysophosphatidic acid receptor-mediated intracellular calcium signaling in early cortical neurogenesis. J Neurosci. 2010 May 26;30(21):7300-9. | |||
| REF 6 | Synthesis and biological evaluation of phosphonic and thiophosphoric acid derivatives of lysophosphatidic acid. Bioorg Med Chem Lett. 2004 Jul 5;14(13):3473-6. | |||
| REF 7 | Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family. J Biol Chem. 2003 Jul 11;278(28):25600-6. | |||
| REF 8 | Screening beta-arrestin recruitment for the identification of natural ligands for orphan G-protein-coupled receptors. J Biomol Screen. 2013 Jun;18(5):599-609. | |||
| REF 9 | G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth. Nat Genet. 2008 Mar;40(3):329-34. | |||
| REF 10 | Lysophosphatidic acid stimulates the G-protein-coupled receptor EDG-1 as a low affinity agonist. J Biol Chem. 1998 Aug 21;273(34):22105-12. | |||
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