Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0X0PP
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| Former ID |
DNCL003117
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| Drug Name |
AMG 579
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| Indication | Schizophrenia [ICD-11: 6A20] | Phase 1 | [1] | |
| Company |
Amgen
|
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| Structure |
 |
Download2D MOL |
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| Formula |
C25H23N5O3
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| Canonical SMILES |
CC(=O)N1CCC(CC1)C2=NC=CN=C2OC3=CC=C(C=C3)C(=O)C4=NC5=CC=CC=C5N4
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| InChI |
1S/C25H23N5O3/c1-16(31)30-14-10-17(11-15-30)22-25(27-13-12-26-22)33-19-8-6-18(7-9-19)23(32)24-28-20-4-2-3-5-21(20)29-24/h2-9,12-13,17H,10-11,14-15H2,1H3,(H,28,29)
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| InChIKey |
ZNPDAYJZIRPRFQ-UHFFFAOYSA-N
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| CAS Number |
CAS 1227067-61-9
|
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Phosphodiesterase 10A (PDE10) | Target Info | Inhibitor | [2] |
| KEGG Pathway | Purine metabolism | |||
| Morphine addiction | ||||
| Pathwhiz Pathway | Purine Metabolism | |||
| Reactome | cGMP effects | |||
| G alpha (s) signalling events | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800035904) | |||
| REF 2 | Discovery of clinical candidate 1-(4-(3-(4-(1H-benzo[d]imidazole-2-carbonyl)phenoxy)pyrazin-2-yl)piperidin-1-yl)ethanone (AMG 579), a potent, selective, and efficacious inhibitor of phosphodiesterase10A (PDE10A). J Med Chem. 2014 Aug 14;57(15):6632-41. | |||
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