Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0X0ER
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| Former ID |
DNC007197
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| Drug Name |
7-chloro-1H-indole-2,3-dione
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| Synonyms |
7-Chloroisatin; 7477-63-6; 7-chloro-1H-indole-2,3-dione; 7-chloroindoline-2,3-dione; 7-chloro-2,3-dihydro-1H-indole-2,3-dione; 7-chloro-2,3-indolinedione; MLS003171490; 1H-INDOLE-2,3-DIONE, 7-CHLORO-; 1H-Indole-2,3-dione,7-chloro-; MFCD00022796; 7-chloro-1H-benzo[d]azolidine-2,3-dione; 7-chlorisatin; 7-chloro isatin; NSC400868; PubChem15537; 7-Chloroisatin, 97%; AC1Q3HYB; AC1L7ZVK; AC1Q3KGY; ACMC-209zr4; 7-Chloroindole-2,3-dione; Isatin-based compound, 43; KSC640I8T; 7-chloro-indoline-2,3-dione; SCHEMBL1247382; CHEMBL222190
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C8H4ClNO2
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| Canonical SMILES |
C1=CC2=C(C(=C1)Cl)NC(=O)C2=O
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| InChI |
1S/C8H4ClNO2/c9-5-3-1-2-4-6(5)10-8(12)7(4)11/h1-3H,(H,10,11,12)
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| InChIKey |
MPLXQMMMGDYXIT-UHFFFAOYSA-N
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| CAS Number |
CAS 7477-63-6
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Liver carboxylesterase (CES1) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Drug metabolism - other enzymes | |||
| Metabolic pathways | ||||
| Pathway Interaction Database | E2F transcription factor network | |||
| WikiPathways | NRF2 pathway | |||
| Nuclear Receptors Meta-Pathway | ||||
| Heroin metabolism | ||||
| Irinotecan Pathway | ||||
| Fluoropyrimidine Activity | ||||
| Phase I biotransformations, non P450 | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Selective inhibition of carboxylesterases by isatins, indole-2,3-diones. J Med Chem. 2007 Apr 19;50(8):1876-85. | |||
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